Model-based versus specific dosimetry in diagnostic context: Comparison of three dosimetric approaches

Abstract : The dosimetric assessment of novel radiotracers represents a legal requirement in most countries. While the techniques for the computation of internal absorbed dose in a therapeutic context have made huge progresses in recent years, in a diagnostic scenario the absorbed dose is usually extracted from model-based lookup tables, most often derived from International Commission on Radiological Protection (ICRP) or Medical Internal Radiation Dose (MIRD) Committee models. The level of approximation introduced by these models may impact the resulting dosimetry. The aim of this work is to establish whether a more refined approach to dosimetry can be implemented in nuclear medicine diagnostics, by analyzing a specific case.
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https://hal.umontpellier.fr/hal-02283129
Contributeur : Mélanie Karli <>
Soumis le : mardi 10 septembre 2019 - 14:56:11
Dernière modification le : vendredi 11 octobre 2019 - 20:23:32

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S. Marcatili, D. Villoing, T. Mauxion, B. Mcparland, M. Bardiès. Model-based versus specific dosimetry in diagnostic context: Comparison of three dosimetric approaches. Medical Physics, American Association of Physicists in Medicine, 2015, 42 (3), pp.1288-1296. ⟨10.1118/1.4907957⟩. ⟨hal-02283129⟩

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