, Colorectal cancer, vol.375, issue.9719, pp.1030-1047, 2010.
Notes from some crypt watchers: Regulation of renewal in the mouse intestinal epithelium, Current Opinion in Cell Biology, vol.10, issue.6, pp.702-709, 1998. ,
The intestinal crypt, a prototype stem cell compartment, Cell, vol.154, issue.2, pp.274-284, 2013. ,
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse, Cell Stem Cell, vol.8, issue.5, pp.511-524, 2011. ,
Crypt stem cells as the cells-of-origin of intestinal cancer, Nature, vol.457, issue.7229, pp.608-611, 2009. ,
Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, vol.449, issue.7165, pp.1003-1007, 2007. ,
Adult intestinal stem cells: Critical drivers of epithelial homeostasis and regeneration, Nature Reviews Molecular Cell Biology, vol.15, issue.1, pp.19-33, 2014. ,
Intestinal development and differentiation, Experimental Cell Research, vol.317, pp.2702-2710, 2011. ,
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells, Cell, vol.143, issue.1, pp.134-144, 2010. ,
Extreme sensitivity of some intestinal crypt cells to X and gamma irradiation, Nature, vol.269, issue.5628, pp.518-521, 1977. ,
, Transcriptional Regulation of the Intestinal Cancer Stem Cell Phenotype
Stem cell dynamics in homeostasis and cancer of the intestine, Nature Reviews Cancer, vol.14, issue.7, pp.468-480, 2014. ,
Stem cells and cancer of the stomach and intestine, Molecular Oncology, vol.4, issue.5, pp.373-384, 2010. ,
The hallmarks of cancer, Cell, vol.100, issue.1, pp.57-70, 2000. ,
Stem cells and cancer: Two faces of eve, Cell, vol.124, issue.6, pp.1111-1115, 2006. ,
Cancer stem cells: An old idea-A paradigm shift, Cancer Research, vol.66, issue.4, pp.1883-1890, 2006. ,
Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells, Molecular and Cellular Biology, vol.27, issue.21, pp.7551-7559, 2007. ,
Major signaling pathways in intestinal stem cells, Biochimica et Biophysica Acta, vol.1830, issue.2, pp.2410-2426, 2013. ,
The canonical Wnt signalling pathway and its APC partner in colon cancer development, Gut, vol.56, issue.3, pp.417-425, 2007. ,
Bmi1 is expressed in vivo in intestinal stem cells, Nature Genetics, vol.40, issue.7, pp.915-920, 2008. ,
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment, Nature Cell Biology, vol.12, issue.5, pp.468-476, 2010. ,
The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres, Molecular Cancer, vol.9, p.212, 2010. ,
Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: A tissue microarray-based analysis, Histopathology, vol.50, issue.4, pp.453-464, 2007. ,
SOX9: A genomic view of tissue specific expression and action, The International Journal of Biochemistry & Cell Biology, vol.87, pp.18-22, 2017. ,
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes, The Journal of Cell Biology, vol.166, issue.1, pp.37-47, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-00266987
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium, The Journal of Cell Biology, vol.178, issue.4, pp.635-648, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00267010
Oncogenicity of the developmental transcription factor Sox9, Cancer Research, vol.72, issue.5, pp.1301-1315, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00768487
Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture, American Journal of Physiology Gastrointestinal and Liver Physiology, vol.302, issue.1, pp.10-20, 2012. ,
SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ss-catenin signaling, Oncotarget, vol.7, issue.50, pp.82228-82243, 2016. ,
Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma, Oncotarget, vol.7, issue.32, pp.50875-50882, 2016. ,
MiniSOX9, a dominant-negative variant in colon cancer cells, Oncogene, vol.30, issue.22, pp.2493-2503, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-02267381
Clinical implications of intestinal stem cell markers in colorectal cancer, Clinical Colorectal Cancer, vol.14, issue.2, pp.63-71, 2015. ,
The pathobiology of Kruppel-like factors in colorectal cancer, Current Colorectal Cancer Reports, vol.4, issue.2, pp.59-64, 2008. ,
Emerging role of KLF4 in human gastrointestinal cancer, Carcinogenesis, vol.27, issue.1, pp.23-31, 2006. ,
Overexpression of Kruppellike factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity, Oncogene, vol.22, issue.22, pp.3424-3430, 2003. ,
Regulation of the potential marker for intestinal cells, Bmi1, by beta-catenin and the zinc finger protein KLF4: Implications for colon cancer, The Journal of Biological Chemistry, vol.287, issue.6, pp.3760-3768, 2012. ,
Role of gut-enriched Kruppel-like factor in colonic cell growth and differentiation, American Journal of Physiology Gastrointestinal and Liver Physiology, vol.279, issue.4, pp.806-814, 2000. ,
Kruppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells, PLoS One, vol.8, issue.2, p.56082, 2013. ,
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell, vol.126, issue.4, pp.663-676, 2006. ,
High KLF4 level in normal tissue predicts poor survival in colorectal cancer patients, World Journal of Surgical Oncology, vol.12, p.232, 2014. ,
Targeting Kruppel-like factor 5 (KLF5) for cancer therapy, Current Topics in Medicinal Chemistry, vol.15, issue.8, pp.699-713, 2015. ,
, Transcriptional Regulation of the Intestinal Cancer Stem Cell Phenotype
KLF5 regulates the integrity and oncogenicity of intestinal stem cells, Cancer Research, vol.74, issue.10, pp.2882-2891, 2014. ,
Kruppellike factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis, Gastroenterology, vol.134, issue.1, pp.120-130, 2008. ,
Notch signaling in stem cell systems, Stem Cells, vol.24, issue.11, pp.2437-2447, 2006. ,
Notch: Architect, landscaper, and guardian of the intestine, Gastroenterology, vol.141, issue.2, pp.448-459, 2011. ,
Role of Notch signaling in colon homeostasis and carcinogenesis, Cancer Science, vol.102, issue.11, pp.1938-1942, 2011. ,
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer, Cancer Research, vol.70, issue.4, pp.1469-1478, 2010. ,
NOTCH signaling regulates asymmetric cell fate of fast-and slow-cycling colon cancer-initiating cells, Cancer Research, vol.76, issue.11, pp.3411-3421, 2016. ,
High level of Notch1 protein is associated with poor overall survival in colorectal cancer, Annals of Surgical Oncology, vol.17, issue.5, pp.1337-1342, 2010. ,
Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch, Development, vol.142, issue.1, pp.41-50, 2015. ,
Bmi-1 promotes the invasion and migration of colon cancer stem cells through the downregulation of E-cadherin, International Journal of Molecular Medicine, vol.38, issue.4, pp.1199-1207, 2016. ,
Self-renewal as a therapeutic target in human colorectal cancer, Nature Medicine, vol.20, issue.1, pp.29-36, 2014. ,
Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: Preclinical and clinical evidences, Stem Cells, vol.30, issue.3, pp.372-378, 2012. ,
Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays, Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, vol.19, issue.5, pp.684-694, 2006. ,
Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer, Journal of Cancer Research and Clinical Oncology, vol.136, issue.7, pp.997-1006, 2010. ,
Polycomb group protein Bmi1 expression in colon cancers predicts the survival, Medical Oncology, vol.27, issue.4, pp.1273-1276, 2010. ,
Hedgehog signaling pathway in colorectal cancer: Function, mechanism, and therapy, OncoTargets and Therapy, vol.10, pp.3249-3259, 2017. ,
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development, Gastroenterology, vol.139, issue.3, pp.893-903, 2010. ,
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth, Nature Communications, vol.7, p.12321, 2016. ,
The prognostic significance of the hedgehog Signaling pathway in colorectal cancer, Clinical Colorectal Cancer, vol.15, issue.2, pp.116-127, 2016. ,
A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer, Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, vol.19, issue.1, pp.258-267, 2013. ,
Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation, International Journal of Cancer, vol.138, issue.11, pp.2700-2712, 2016. ,
Regulation of intestinal cancer stem cells, Cancer Letters, vol.338, issue.1, pp.120-126, 2013. ,
BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes, Nature Communications, vol.8, p.13824, 2017. ,
Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice, Gastroenterology, vol.140, issue.1, pp.297-309, 2011. ,
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression, Nature Cell Biology, vol.16, issue.7, pp.695-707, 2014. ,
A meta-analysis of SMAD4 immunohistochemistry as a prognostic marker in colorectal cancer, Translational Oncology, 2015. ,
The hippo signaling pathway in development and cancer, Developmental Cell, vol.19, issue.4, pp.491-505, 2010. ,
The hippo signaling pathway in stem cell biology and cancer, EMBO Reports, vol.15, issue.6, pp.642-656, 2014. ,
Intersection of Hippo/YAP and Wnt/beta-catenin signaling pathways, Acta Biochimica et Biophysica Sinica (Shanghai), vol.45, issue.2, pp.71-79, 2013. ,
Multiple roles for the hippo effector yap in gut regeneration and cancer initiation, Molecular & Cellular Oncology, vol.3, issue.3, p.1143992, 2016. ,
Clinical and prognostic significance of Yes-associated protein in colorectal cancer, Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine, vol.34, issue.4, pp.2169-2174, 2013. ,
Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis, Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, vol.20, issue.4, pp.837-846, 2014. ,
Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk, Expert Opinion on Drug Metabolism & Toxicology, vol.12, issue.9, pp.997-1010, 2016. ,
Activating and inhibitory functions of WNT/beta-catenin in the induction of cytochromes P450 by nuclear receptors in HepaRG cells, Molecular Pharmacology, vol.87, issue.6, pp.1013-1020, 2015. ,
Pregnane X-receptor promotes stem cell-mediated colon cancer relapse, Oncotarget, vol.7, issue.35, pp.56558-56573, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01431926
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice, The Journal of Clinical Investigation, vol.121, issue.8, pp.3220-3232, 2011. ,
Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer, Molecular Cancer, vol.16, issue.1, p.71, 2017. ,
Interconversion between intestinal stem cell populations in distinct niches, Science, vol.334, issue.6061, pp.1420-1424, 2011. ,
Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer, Neoplasia, vol.14, issue.7, pp.559-571, 2012. ,
The homeobox only protein homeobox (HOPX) and colorectal cancer, International Journal of Molecular Sciences, vol.14, issue.12, pp.23231-23243, 2013. ,
The role of the ubiquitously expressed transcription factor Sp1 in tissue-specific transcriptional regulation and in disease, The Yale Journal of Biology and Medicine, vol.89, issue.4, pp.513-525, 2016. ,
Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts, Oncology Reports, vol.30, issue.4, pp.1782-1792, 2013. ,
, Transcriptional Regulation of the Intestinal Cancer Stem Cell Phenotype