P. Chambon, A decade of molecular biology of retinoic acid receptors, FASEB J, vol.10, issue.9, p.8801176, 1996.

P. Germain, P. Chambon, G. Eichele, R. M. Evans, M. A. Lazar et al., International Union of Pharmacology. LX. Retinoic acid receptors, Pharmacol Rev, vol.58, issue.4, p.17132850, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00187922

M. Mark, N. B. Ghyselinck, and P. Chambon, FUNCTION OF RETINOID NUCLEAR RECEPTORS: Lessons from Genetic and Pharmacological Dissections of the Retinoic Acid Signaling Pathway During Mouse Embryogenesis, Annu Rev Pharmacol Toxicol, vol.46, p.16402912, 2006.

P. Germain, B. Staels, C. Dacquet, M. Spedding, and V. Laudet, Overview of nomenclature of nuclear receptors, Pharmacol Rev, vol.58, issue.4, p.17132848, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00187929

C. Rochette-egly and P. Germain, Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs), Nucl Recept Signal, vol.7, p.5, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00420158

P. Germain, J. Iyer, C. Zechel, and H. Gronemeyer, Coregulator recruitment and the mechanism of retinoic acid receptor synergy, Nature, vol.415, p.11805839, 2002.

J. P. Renaud, N. Rochel, M. Ruff, V. Vivat, P. Chambon et al., Crystal structure of the RARgamma ligand-binding domain bound to all-trans retinoic acid, Nature, vol.378, issue.6558, p.7501014, 1995.

W. Bourguet, V. Vivat, J. M. Wurtz, P. Chambon, H. Gronemeyer et al., Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains, Mol Cell, vol.5, issue.2, p.10882070, 2000.

B. P. Klaholz, A. Mitschler, and D. Moras, Structural basis for isotype selectivity of the human retinoic acid nuclear receptor, J Mol Biol, vol.302, issue.1, p.10964567, 2000.

P. Germain, S. Kammerer, E. Perez, C. Peluso-iltis, D. Tortolani et al., Rational design of RARselective ligands revealed by RARbeta crystal stucture, EMBO Rep, vol.5, issue.9, p.15319780, 2004.

V. Pogenberg, J. F. Guichou, V. Vivat-hannah, S. Kammerer, E. Perez et al., Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies, J Biol Chem, vol.280, issue.2, p.15528208, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00187727

A. Le-maire, C. Teyssier, C. Erb, M. Grimaldi, S. Alvarez et al., A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor, Nature Structural & Molecular Biology, vol.17, issue.7, pp.801-844, 2010.

R. Alvarez, B. Vaz, H. Gronemeyer, and A. R. De-lera, Functions, therapeutic applications, and synthesis of retinoids and carotenoids, Chem Rev, vol.114, issue.1, p.24266866, 2014.

L. Altucci and H. Gronemeyer, The promise of retinoids to fight against cancer, Nat Rev Cancer, vol.1, issue.3, p.11902573, 2001.

M. A. Ortiz, Y. Bayon, F. J. Lopez-hernandez, and F. J. Piedrafita, Retinoids in combination therapies for the treatment of cancer: mechanisms and perspectives, Drug Resist Updat, vol.5, issue.3-4, p.12531180, 2002.

S. Y. Sun and R. Lotan, Retinoids and their receptors in cancer development and chemoprevention, Crit Rev Oncol Hematol, vol.41, issue.1, p.11796231, 2002.

M. I. Dawson, Synthetic retinoids and their nuclear receptors, Curr Med Chem Anticancer Agents, vol.4, issue.3, p.15134501, 2004.

H. Kagechika and K. Shudo, Synthetic retinoids: recent developments concerning structure and clinical utility, J Med Chem, vol.48, p.16161990, 2005.

A. Le-maire, S. Alvarez, P. Shankaranarayanan, A. R. Lera, W. Bourguet et al., Retinoid receptors and therapeutic applications of RAR/RXR modulators, Curr Top Med Chem, vol.12, issue.6, p.22242853, 2012.

M. Gehin, V. Vivat, J. M. Wurtz, R. Losson, P. Chambon et al., Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists, Chem Biol, vol.6, issue.8, p.10421757, 1999.

H. Kagechika, E. Kawachi, Y. Hashimoto, T. Himi, and K. Shudo, Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity, J Med Chem, vol.31, issue.11, p.3184125, 1988.

S. Alvarez, P. Germain, R. Alvarez, F. Rodriguez-barrios, H. Gronemeyer et al., Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor, Int J Biochem Cell Biol, vol.39, issue.7-8, pp.1406-1421, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00189381

T. N. Faria, C. Mendelsohn, P. Chambon, and L. J. Gudas, The targeted disruption of both alleles of RARbeta(2) in F9 cells results in the loss of retinoic acid-associated growth arrest, J Biol Chem, vol.274, issue.38, p.10480883, 1999.

R. Lotan, X. C. Xu, S. M. Lippman, J. Y. Ro, J. S. Lee et al., Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin, N Engl J Med, vol.332, issue.21, p.7723796, 1995.

L. Castillo, G. Milano, J. Santini, F. Demard, and V. Pierrefite, Analysis of retinoic acid receptor beta expression in normal and malignant laryngeal mucosa by a sensitive and routine applicable reverse transcriptionpolymerase chain reaction enzyme-linked immunosorbent assay method, Clin Cancer Res, vol.3, issue.11, p.9815607, 1997.

D. M. Shin, X. C. Xu, S. M. Lippman, J. J. Lee, J. S. Lee et al., Accumulation of p53 protein and retinoic acid receptor beta in retinoid chemoprevention, Clin Cancer Res, vol.3, issue.6, p.9815762, 1997.

M. Widschwendter, J. Berger, H. M. Muller, A. G. Zeimet, and C. Marth, Epigenetic downregulation of the retinoic acid receptor-beta2 gene in breast cancer, J Mammary Gland Biol Neoplasia, vol.6, issue.2, p.11501579, 2001.

S. M. Sirchia, M. Ren, R. Pili, E. Sironi, G. Somenzi et al., Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer, Cancer Res, vol.62, issue.9, p.11980632, 2002.

X. Liu, M. Nugoli, J. Laferriere, S. M. Saleh, I. G. Rodrigue-gervais et al., Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis, Proc Natl Acad Sci U S A, vol.108, issue.2, p.21187396, 2011.

J. Y. Chen, S. Penco, J. Ostrowski, P. Balaguer, M. Pons et al., RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation, Embo J, vol.14, issue.6, p.7720709, 1995.

E. S. Klein, M. E. Pino, A. T. Johnson, P. J. Davies, S. Nagpal et al., Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists, J Biol Chem, vol.271, issue.37, p.8798442, 1996.

P. Germain, C. Gaudon, V. Pogenberg, S. Sanglier, A. Van-dorsselaer et al., Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists, Chem Biol, vol.16, issue.5, pp.479-89, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00420381

J. Osz, Y. Brelivet, C. Peluso-iltis, V. Cura, S. Eiler et al., Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors, Proc Natl Acad Sci U S A, vol.109, issue.10, p.22355136, 2012.

Y. Li, Y. Hashimoto, A. Agadir, H. Kagechika, and X. Zhang, Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acidinduced apoptosis in human breast cancer cells, J Biol Chem, vol.274, issue.22, p.10336422, 1999.

S. Alvarez, H. Khanwalkar, R. Alvarez, C. Erb, C. Martinez et al., C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function, ChemMedChem, vol.4, issue.10, pp.1630-1670, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00438635

C. Martinez, M. Lieb, S. Alvarez, F. Rodriguez-barrios, R. Alvarez et al., Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scaffold, ACS Med Chem Lett, vol.5, issue.5, pp.533-540, 2014.

W. Kabsch, Integration, scaling, space-group assignment and post-refinement, Acta Crystallogr D Biol Crystallogr, vol.66, issue.2, pp.133-177, 2010.

P. D. Adams, P. V. Afonine, G. Bunkoczi, V. B. Chen, I. W. Davis et al., PHENIX: a comprehensive Python-based system for macromolecular structure solution, Acta Crystallogr D Biol Crystallogr, vol.66, issue.2, pp.213-234, 2010.

P. Emsley and K. Cowtan, Coot: model-building tools for molecular graphics, Acta Crystallogr D Biol Crystallogr, vol.60, p.15572765, 2004.

G. N. Murshudov, A. A. Vagin, and E. J. Dodson, Refinement of macromolecular structures by the maximum-likelihood method, Acta Crystallogr D Biol Crystallogr, vol.53, p.15299926, 1997.

M. D. Winn, C. C. Ballard, K. D. Cowtan, E. J. Dodson, P. Emsley et al., Overview of the CCP4 suite and current developments, Acta Crystallogr D Biol Crystallogr, vol.67, pp.235-277, 2011.