Chemical and pharmacological study of higher fungi. I. Chemical composition and pharmacological investigation carpophores of Cortinarius armillatus (Fr.:Fr.) Fr. (Cortinariaceae)

Abstract : The fruit bodies of Cortinarius armillatus were investigated for polyols, tree sugars and amino acids, phenolic acids, alkaloids, nitrogen content compounds, glycosides and fungal toxins using thin-layer chromatography and qualitative chemical reactions. Arabitol, mannitol, trehalose, fructose, 4-hydroxybenzoic acid, cholin, alanine, proline, serine, asparagine, glycosides and cortinarin A were detected in aqueous and methanolic extracts from the mushroom. Valine, methionine, glutaminic acid and fungal toxins (α-amanitin, orellanine, rauscarine, muscimol, bufotenine) were not observed within C. armillatus. The single intraperitoneal doses of the methanolic extract from C. armillatus havenot been toxic and no induced effects organic pathology up to 2000 mg/kg two weeks after injection to mice. These chemical studies and acute toxicity investigations supported the non-toxicity of C. armillatus. At the content of some chemical substances (4-hydroxybenzoic acid, cholin, steroid glycosides, cortinarin A) this species may be perspective for a further pharmacological investigations.
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Soumis le : vendredi 2 août 2019 - 08:33:11
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Susanna M. Badalyan, Sylvie Rapior, Lucette Doko, J. Le Quang, Maurice Jacob, et al.. Chemical and pharmacological study of higher fungi. I. Chemical composition and pharmacological investigation carpophores of Cortinarius armillatus (Fr.:Fr.) Fr. (Cortinariaceae). Mikologiya i Fitopatologiya, 1996, 30 (3), pp.37-42. ⟨hal-02262161⟩

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