Amatoxin poisoning treatment decision-making: pharmaco-therapeutic clinical strategy assessment using multidimensional multivariate statistic analysis

Abstract : Ninety percent of fatal higher fungus poisoning is due to amatoxin-containing mushroom species. In addition to absence of antidote, no chemotherapeutic consensus was reported. The aim of the present study is to perform a retrospective multidimensional multivariate statistic analysis of 2110 amatoxin poisoning clinical cases, in order to optimize therapeutic decision-making. Our results allowed to classify drugs as a function of their influence on one major parameter: patient survival. Active principles were classified as first intention, second intention, adjuvant or controversial pharmaco-therapeutic clinical intervention. We conclude that (1) retrospective multidimensional multivariate statistic analysis of complex clinical dataset might help future therapeutic decision-making and (2) drugs such as silybin, N-acetylcystein and putatively ceftazidime are clearly associated, in amatoxin poisoning context, with higher level of patient survival.
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https://hal.umontpellier.fr/hal-02196299
Contributeur : Sylvie Rapior <>
Soumis le : samedi 27 juillet 2019 - 18:10:16
Dernière modification le : vendredi 23 août 2019 - 11:38:03

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Patrick Poucheret, Françoise Fons, Jean Christophe Doré, Didier Michelot, Sylvie Rapior. Amatoxin poisoning treatment decision-making: pharmaco-therapeutic clinical strategy assessment using multidimensional multivariate statistic analysis. Toxicon, Elsevier, 2010, 55 (7), pp.1338-1345. ⟨10.1016/j.toxicon.2010.02.005⟩. ⟨hal-02196299⟩

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