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, Acknowledgements We thank Patrick Parra and Jean-Yves Tiercelin for custom-made high-precision mechanics
, Amparo Ruiz Vera and Odile Lecquyer for the management of the Embryomics and BioEmergences EC projects
Valérie Lavallée and Simon Agostini for fish care ,
DNA constructs (mCherry and eGFP-HRAS, respectively) ,
, Pascal Abbas for technical assistance; the N&D and ISC-PIF staff for administrative support
This work was supported by grants EC NEST 'Adventure' 012916, EC NEST 'Measuring the Impossible' 28892, ZF-Health EC project HEALTH-F4-2010-242048, ACI STIC santé, Dominique De Waleffe from DENALI SA for his contribution to the BioEmergences EC project's workflow interface ,
coordinated the workflow development, the manuscript preparation and performed the software comparison ,
developed the visualization interface Mov-IT and the BioEmergences web service ,
developed the Gaussian-based nucleus centre detection method; C.M. developed the cell tracking method and contributed to the workflow development ,
developed filtering and nucleus centre detection methods ,
contributed to the specification of the Mov-IT functionalities and organization of the BioEmergences database; R.S. developed the embryo shape segmentation method and contributed to the workflow development ,
contributed to the workflow development, in both its standalone and web service versions ,
developed algorithm parallelization tools ,
coordinated the specification of the Mov-IT functionalities and organization of the BioEmergences database ,
worked on the reconstruction validation and standardization of error assessment ,
conducted imaging experiments, data validation and correction ,
conducted imaging experiments, data validation and correction; J.K. provided engineering support to the computation ,
,
conducted data validation and correction ,
led the molecular biology of embryo staining; Y.K. co-supervised the design and implementation of the tracking method, and co-wrote the manuscript ,
custom-designed the MLSM coupling and designed the imaging strategies ,
co-coordinated the project, co-developed nucleus and membrane segmentation methods and co-wrote the manuscript ,
co-coordinated the project, co-designed cell tracking methods and co-wrote the manuscript ,
co-coordinated the project, and led several algorithm designs ,
co-coordinated the project, led several algorithm designs, and co-wrote the manuscript; N.P. co-founded and co-coordinated the project, led the biological relevance and co-wrote the manuscript ,
co-founded and co-coordinated the project, designed the formal and epistemological framework and co-wrote the manuscript ,