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, Green anole AnoCar2.0, Frog 1441 JGI4.2, Fugu FUGU4.0 and Zebrafish GRCz10. The syntenic conserved orthologs or gene 1442 blocks are shown in matching colors. Asterisks (*) next to the chromosome (Ch) or scaffold 1443 (scaf) name indicate that the orientation was

, Intron/Exon organization and length of the IL10R1 gene in various vertebrate species. The 1445

, While exons retained the same length, intron size varied among 1451 species with chicken and fugu in particular, being the most compacted. Common carp 1452 expresses two copies of the CRFB7 gene, but the genome assembly is still incomplete to 1453 provide synteny information on the position of these genes in the carp genome. C), Green anole sequence (as well as the one of other reptile IL10R1) is still incomplete in the 1446 database and was not included

, Tetraodon is an exception to all species as it presents two 1459 non-canonical sites (dark green) with substantially diverged sequences but at conserved 1460 57 positions with respect to the ones found in other vertebrates. In grey are the additional 1461 STAT3-binding sites found upstream of the canonical ones in some mammalian and avian 1462 sequences. In almost all sequences, an additional tyrosine (Y) residue is found downstream 58 schematics were constructed using http://wormweb.org/exonintron and the intron/exon 1485 length information was retrieved from ensembl. The numbers on the introns of the human 1486 gene denote the phase of the intron, which is conserved in all species (not shown). Note the 1487 conservation of the gene structure with 7 exons and 6 introns

, Upregulation of IL10 (blue line) occurs in a later phase of the infection, 1494 followed by a downregulation of pro-inflammatory genes, an increase in specific 1495 antibodies, and ultimately by a reduced parasite burden. In contrast, in susceptible lines, an 1496 early expression of IL10 is observed, prior to a very modest upregulation of pro-1497 inflammatory genes. This leads to an uncontrolled parasite replication and increased 1498 mortalities, Trypanoplasma borreli infection. In resistant strains, the peak of pro-inflammatory 1492 molecules expression (iNOS