Flotillins control zebrafish epiboly through their role in cadherin-mediated cell-cell adhesion

Eduardo Rios 1, 2 Stéphane Bodin 1 Bénédicte Delaval 1 Franck Comunale 1 Virginie Georget 1 Manoel Costa 2 Georges Lutfalla 3 Cécile Gauthier-Rouvière 1
1 CRBM - Centre de recherche en Biologie Cellulaire
2 UFRJ - Universidade Federal do Rio de Janeiro [Rio de Janeiro]
3 DIMNP - Dynamique des interactions membranaires normales et pathologiques
Abstract : Zebrafish gastrulation and particularly epiboly that involves coordinated movements of several cell layers is a dynamic process for which regulators remain to be identified. We show here that Flotillin 1 and 2, ubiquitous and highly conserved proteins, are required for epiboly. Flotillins knockdown compromised embryo survival, strongly delayed epiboly and impaired deep cell radial intercalation and directed collective migration without affecting enveloping layer cell movement. At the molecular level, we identified that Flotillins are required for the formation of E‐cadherin‐mediated cell–cell junctions. These results provide the first in vivo evidence that Flotillins regulate E‐cadherin‐mediated cell–cell junctions to allow epiboly progression.
Keywords : Zebrafish Gastrulation Flotillins E-cadherin
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Dernière modification le : lundi 17 juin 2019 - 15:56:02
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UNIV-MONTPELLIER | CNRS | BS

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Eduardo Rios, Stéphane Bodin, Bénédicte Delaval, Franck Comunale, Virginie Georget, et al.. Flotillins control zebrafish epiboly through their role in cadherin-mediated cell-cell adhesion. Biology of the Cell, Wiley, 2017, 109 (5), pp.210-221. ⟨10.1111/boc.201700001⟩. ⟨hal-02086747⟩

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