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Article dans une revue
Flotillins control zebrafish epiboly through their role in cadherin-mediated cell-cell adhesion
Abstract : Zebrafish gastrulation and particularly epiboly that involves coordinated movements of several cell layers is a dynamic process for which regulators remain to be identified. We show here that Flotillin 1 and 2, ubiquitous and highly conserved proteins, are required for epiboly. Flotillins knockdown compromised embryo survival, strongly delayed epiboly and impaired deep cell radial intercalation and directed collective migration without affecting enveloping layer cell movement. At the molecular level, we identified that Flotillins are required for the formation of E‐cadherin‐mediated cell–cell junctions. These results provide the first in vivo evidence that Flotillins regulate E‐cadherin‐mediated cell–cell junctions to allow epiboly progression.
Littérature citée [52 références]
https://hal.umontpellier.fr/hal-02086747
Contributeur : Georges Lutfalla <>
Soumis le : lundi 1 avril 2019 - 15:31:06
Dernière modification le : mardi 24 novembre 2020 - 16:42:03
Archivage à long terme le : : mardi 2 juillet 2019 - 14:20:24
Contributeur : Georges Lutfalla <>
Soumis le : lundi 1 avril 2019 - 15:31:06
Dernière modification le : mardi 24 novembre 2020 - 16:42:03
Archivage à long terme le : : mardi 2 juillet 2019 - 14:20:24
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morrisEduardo2017.pdf
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