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ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB Michèle Leduc 58561-0 Joy Richard 1548713-0 Safia Costes 3f0deaeddfa0fb421fa4d08a0ab31d28 igf.cnrs.fr 1082458 252518-1082458 Dany Muller 950697-0 Annie Varrault 6afbb7dcbbafe056a51efaa5fe6ea98d igf.cnrs.fr avarrault 742536 4679-742536 Vincent Compan 3d585c02cf8c051e7073799bf07ca26e igf.cnrs.fr vincent-compan 183207 7342-183207 https://www.idref.fr/084250747 https://orcid.org/0000-0001-6805-1179 Julia Mathieu 1372362-0 Jean-François Tanti 8109b1c7825d4a58d2483928963f4e22 unice.fr jean-francois-tanti 741098 150419-741098 https://orcid.org/0000-0003-1782-1318 https://www.idref.fr/034190511 Gilles Pagès 212355ca3efea1c9f18b769f5fde57d8 unice.fr gilles-pages 8458 7298-8458 https://www.idref.fr/030737605 https://orcid.org/0000-0001-6487-3079 Jacques Pouysségur 350306-0 Gyslaine Bertrand c171ae74ee25d0626fb3388617e682b9 igf.cnrs.fr gyslaine-bertrand 1082459 252583-1082459 Stéphane Dalle 3a8dc0a56da53679c6e8aeaa9f5fdcac chu-lyon.fr stephanedalle 937229 252520-937229 https://orcid.org/0000-0002-3423-4548 https://www.idref.fr/075987279 Magalie A Ravier af16f469f3b1c57347d1751fb2754f33 igf.cnrs.fr magalie-ravier 183213 28884-183213 https://orcid.org/0000-0001-6607-6559 https://www.idref.fr/204006899 Sandrine KUHN-BERAUD 2ccd6335cd759a0ebcbc3c68c1549311 umontpellier.fr 2019-03-19 15:29:04 2025-06-23 11:29:06 2019-03-19 15:29:04 2017-10 contributor Sandrine KUHN-BERAUD 2ccd6335cd759a0ebcbc3c68c1549311 umontpellier.fr CCSD hal-02073008 https://hal.umontpellier.fr/hal-02073008 leduc:hal-02073008 <i>Diabetologia</i>, 2017, 60 (10), pp.1999-2010. <a target="_blank" href="https://dx.doi.org/10.1007/s00125-017-4356-6">⟨10.1007/s00125-017-4356-6⟩</a> Diabetologia, 2017, 60 (10), pp.1999-2010. ⟨10.1007/s00125-017-4356-6⟩ Université Nice Sophia Antipolis CNRS - Centre national de la recherche scientifique Institut de génomique fonctionnelle Biologie-Santé Université de Montpellier Université Côte d'Azur Collection test HAL CNRS Collection du Centre Méditerranéen de Médecine Moléculaire Institut de Recherche sur le Cancer et le Vieillissement Université de Montpellier (2015-2021) Fondation pour la Recherche Médicale UNIV-COTEDAZUR_COLLECTION_DEFAUT test nice International No Yes ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB Michèle Leduc 58561-0 Joy Richard 1548713-0 Safia Costes 3f0deaeddfa0fb421fa4d08a0ab31d28 igf.cnrs.fr 1082458 252518-1082458 Dany Muller 950697-0 Annie Varrault 6afbb7dcbbafe056a51efaa5fe6ea98d igf.cnrs.fr avarrault 742536 4679-742536 Vincent Compan 3d585c02cf8c051e7073799bf07ca26e igf.cnrs.fr vincent-compan 183207 7342-183207 https://www.idref.fr/084250747 https://orcid.org/0000-0001-6805-1179 Julia Mathieu 1372362-0 Jean-François Tanti 8109b1c7825d4a58d2483928963f4e22 unice.fr jean-francois-tanti 741098 150419-741098 https://orcid.org/0000-0003-1782-1318 https://www.idref.fr/034190511 Gilles Pagès 212355ca3efea1c9f18b769f5fde57d8 unice.fr gilles-pages 8458 7298-8458 https://www.idref.fr/030737605 https://orcid.org/0000-0001-6487-3079 Jacques Pouysségur 350306-0 Gyslaine Bertrand c171ae74ee25d0626fb3388617e682b9 igf.cnrs.fr gyslaine-bertrand 1082459 252583-1082459 Stéphane Dalle 3a8dc0a56da53679c6e8aeaa9f5fdcac chu-lyon.fr stephanedalle 937229 252520-937229 https://orcid.org/0000-0002-3423-4548 https://www.idref.fr/075987279 Magalie A Ravier af16f469f3b1c57347d1751fb2754f33 igf.cnrs.fr magalie-ravier 183213 28884-183213 https://orcid.org/0000-0001-6607-6559 https://www.idref.fr/204006899 12578 0012-186X 1432-0428 Diabetologia Springer Verlag 60 10 1999-2010 2017-10 10.1007/s00125-017-4356-6 28721437 English ERK1/2 CREB Ageing Pancreatic islet biology p90RSK Peri-insulitis Insulin secretion MSK1 Pancreatic beta cell mass Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Journal articles Journal articles Journal articles

Insufficient insulin secretion from pancreatic beta cells, which is associated with a decrease in beta cell mass, is a characteristic of type 2 diabetes. Extracellular signal-related kinase 1 and 2 (ERK1/2) inhibition in beta cells has been reported to affect insulin secretion, gene transcription and survival, although whether ERK1 and ERK2 play distinct roles is unknown. The aim of this study was to assess the individual roles of ERK1 and ERK2 in beta cells using ERK1 (also known as Mapk3)-knockout mice (Erk1 -/- mice) and pharmacological approaches.

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