Prevalence and Gene Characteristics of Antibodies with Cofactor-induced HIV-1 Specificity

Abstract : Background: Normal immune repertoires have a fraction of cofactor-binding antibodies. Results: Heme exposure results in acquisition of reactivity to gp120 HIV-1 in 24% of antibodies in a seronegative immune repertoire; these antibodies have less mutated variable regions. Conclusion: Human immune repertoires contain high frequency of antibodies with cofactor-induced antigen specificities. Significance: This work enhances understanding of molecular features of heme-sensitive Abs and their contribution to diversification of the immune repertoires.
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https://hal.umontpellier.fr/hal-02067196
Contributeur : Mélanie Karli <>
Soumis le : jeudi 14 mars 2019 - 09:52:02
Dernière modification le : jeudi 13 juin 2019 - 11:14:03

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Maxime Lecerf, Tobias Scheel, Anastas D. Pashov, Annaëlle Jarossay, Delphine Ohayon, et al.. Prevalence and Gene Characteristics of Antibodies with Cofactor-induced HIV-1 Specificity. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (8), pp.5203-5213. ⟨10.1074/jbc.M114.618124⟩. ⟨hal-02067196⟩

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