B. B. Petrovska, Historical review of medicinal plants' usage, Pharmacogn Rev, vol.6, issue.11, p.3358962, 2012.

T. Sen and S. K. Samanta, Medicinal plants, human health and biodiversity: a broad review, Adv Biochem Eng Biotechnol, vol.147, pp.59-110, 2015.

N. J. Sucher and M. C. Carles, A pharmacological basis of herbal medicines for epilepsy, Epilepsy Behav, vol.52, p.26074183, 2015.

F. E. Koehn and G. T. Carter, The evolving role of natural products in drug discovery, Nat Rev Drug Discov, vol.4, issue.3, pp.206-226, 2005.

G. Woronuk, Z. Demissie, M. Rheault, and M. S. , Biosynthesis and therapeutic properties of Lavandula essential oil constituents, Planta Med, vol.77, issue.1, p.20665367, 2011.

P. H. Koulivand, K. Ghadiri, M. Gorji, and A. , Lavender and the nervous system, Evid Based Complement Alternat Med, p.3612440, 2013.

S. N. Ngo, D. B. Williams, and R. J. Head, Rosemary and cancer prevention: preclinical perspectives, Crit Rev Food Sci Nutr, vol.51, issue.10, p.21955093, 2011.

H. M. Cavanagh and J. M. Wilkinson, Biological activities of lavender essential oil, Phytother Res, vol.16, issue.4, p.12112282, 2002.

A. H. Gilani, N. Aziz, M. A. Khan, F. Shaheen, Q. Jabeen et al., Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L, J Ethnopharmacol, vol.71, issue.1-2, p.10904159, 2000.

A. M. Schuwald, M. Noldner, T. Wilmes, N. Klugbauer, K. Leuner et al., Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels, PLoS One, vol.8, issue.4, p.3639265, 2013.

J. Lehrner, G. Marwinski, S. Lehr, P. Johren, and L. Deecke, Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office, Physiol Behav, vol.86, issue.1-2, p.16095639, 2005.

M. Herrero, M. Plaza, A. Cifuentes, and E. Ibanez, Green processes for the extraction of bioactives from Rosemary: Chemical and functional characterization via ultra-performance liquid chromatography-tandem mass spectrometry and in-vitro assays, J Chromatogr A, vol.1217, issue.16, pp.2512-2532, 2010.

C. Xiao, H. Dai, H. Liu, Y. Wang, and H. Tang, Revealing the metabonomic variation of rosemary extracts using 1H NMR spectroscopy and multivariate data analysis, J Agric Food Chem, vol.56, issue.21, pp.10142-53, 2008.

M. E. Gonzalez-trujano, E. I. Pena, A. L. Martinez, J. Moreno, P. Guevara-fefer et al., Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents, J Ethnopharmacol, vol.111, issue.3, p.17223299, 2007.

I. Takaki, L. E. Bersani-amado, A. Vendruscolo, S. M. Sartoretto, S. P. Diniz et al., Antiinflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models, J Med Food, vol.11, issue.4, pp.741-747, 2008.

S. E. Park, S. Kim, K. Sapkota, and S. J. Kim, Neuroprotective effect of Rosmarinus officinalis extract on human dopaminergic cell line, SH-SY5Y, Cell Mol Neurobiol, vol.30, issue.5, pp.759-67, 2010.

M. Ozarowski, P. L. Mikolajczak, A. Bogacz, A. Gryszczynska, M. Kujawska et al., Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and

L. M. Hondeghem and B. G. Katzung, Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs, Annu Rev Pharmacol Toxicol, vol.24, p.6203481, 1984.

S. Hering, S. Aczel, R. L. Kraus, S. Berjukow, J. Striessnig et al., Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: role of inactivation, Proc Natl Acad Sci U S A, vol.94, issue.24, p.24307, 1997.

P. Gonzalez-rodriguez, D. Falcon, M. J. Castro, J. Urena, J. Lopez-barneo et al., Hypoxic induction of T-type Ca(2+) channels in rat cardiac myocytes: role of HIF-1alpha and RhoA/ROCK signalling, J Physiol, vol.593, issue.21, pp.4729-4774, 2015.

P. Central and P. , , p.4626545

V. Carabelli, A. Marcantoni, V. Comunanza, A. De-luca, J. Diaz et al., Chronic hypoxia up-regulates alpha1H T-type channels and low-threshold catecholamine secretion in rat chromaffin cells, J Physiol, vol.584, p.2277059, 2007.

P. Mariot, K. Vanoverberghe, N. Lalevee, M. F. Rossier, and N. Prevarskaya, Overexpression of an alpha 1H (Cav3.2) T-type calcium channel during neuroendocrine differentiation of human prostate cancer cells, J Biol Chem, vol.277, issue.13, p.11799114, 2002.
URL : https://hal.archives-ouvertes.fr/hal-01619068

K. L. Powell, S. M. Cain, T. P. Snutch, O. 'brien, and T. J. , Low threshold T-type calcium channels as targets for novel epilepsy treatments, Br J Clin Pharmacol, vol.77, issue.5, p.4004393, 2014.

E. Tsakiridou, L. Bertollini, M. De-curtis, G. Avanzini, and H. C. Pape, Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy, J Neurosci, vol.15, issue.4, p.7722649, 1995.

S. Sakkaki, G. Gangarossa, B. Lerat, D. Francon, L. Forichon et al., Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model, Neuropharmacology, vol.101, p.26456350, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01936765

P. Lory and J. Chemin, Towards the discovery of novel T-type calcium channel blockers, Expert Opin Ther Targets, vol.11, issue.5, p.17465728, 2007.

J. C. Gomora, A. N. Daud, M. Weiergraber, and E. Perez-reyes, Block of cloned human T-type calcium channels by succinimide antiepileptic drugs, Mol Pharmacol, vol.60, issue.5, p.11641441, 2001.

E. Tringham, K. L. Powell, S. M. Cain, K. Kuplast, J. Mezeyova et al., T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures, Sci Transl Med, vol.4, issue.121, p.22344687, 2012.

R. R. Llinas, U. Ribary, D. Jeanmonod, E. Kronberg, and P. P. Mitra, Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography, Proc Natl Acad Sci U S A, vol.96, issue.26, p.24801, 1999.

N. D. Berger, V. M. Gadotti, R. R. Petrov, K. Chapman, P. Diaz et al., NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors, Mol Pain, vol.10, p.4271433, 2014.

M. M. Jagodic, S. Pathirathna, P. M. Joksovic, W. Lee, M. T. Nelson et al., Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve, J Neurophysiol, vol.99, issue.6, p.18417624, 2008.

P. Central and P. , , p.2667888

L. Huang, B. M. Keyser, T. M. Tagmose, J. B. Hansen, J. T. Taylor et al., NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2, 3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels, J Pharmacol Exp Ther, vol.309, issue.1, p.14718587, 2004.

F. Y. Shen, Z. Y. Chen, W. Zhong, L. Q. Ma, C. Chen et al., Alleviation of neuropathic pain by regulating T-type calcium channels in rat anterior cingulate cortex, Mol Pain, vol.11, p.4357203, 2015.

M. F. Jarvis, V. E. Scott, S. Mcgaraughty, K. L. Chu, J. Xu et al., A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats, Biochem Pharmacol, vol.89, issue.4, p.24726441, 2014.

D. Ziegler, W. R. Duan, A. G. Thomas, J. W. Nothaft, and W. , A randomized double-blind, placebo-, and activecontrolled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain, Pain, vol.156, issue.10, p.4770341, 2015.

J. Serra, W. R. Duan, C. Locke, R. Sola, W. Liu et al., Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial, Pain, vol.156, issue.11, p.26035253, 2015.

M. Lee, Z944: a first in class T-type calcium channel modulator for the treatment of pain, J Peripher Nerv Syst, vol.19, p.25269728, 2014.

M. Bialer, S. I. Johannessen, R. H. Levy, E. Perucca, T. Tomson et al., Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII), Epilepsy Res, vol.111, p.25769377, 2015.

T. D. Hill, M. G. Cascio, B. Romano, M. Duncan, R. G. Pertwee et al., Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism, Br J Pharmacol, vol.170, issue.3, p.3792005, 2013.

R. D. Hosking and J. P. Zajicek, Therapeutic potential of cannabis in pain medicine, Br J Anaesth, vol.101, issue.1, pp.59-68, 2008.