Natural payload delivery of the doxorubicin anticancer drug from boron nitride oxide nanosheets - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Applied Surface Science Année : 2019

Natural payload delivery of the doxorubicin anticancer drug from boron nitride oxide nanosheets

Résumé

We studied the behavior of doxorubicin (DOX; an anticancer drug) molecules loaded on a boron nitride oxide nanosheet (BNO-NS) using the density functional theory (DFT), time-dependent density functional theory (TDDFT), and molecular dynamic (MD) simulation methods. We found that DOX molecules in pi-pi or covalent interaction with BNO-NS preserve their optical properties in water. Moreover, the BNO-NS vector allowed stabilizing the DOX molecules on a cellular membrane contrary to isolated DOX that randomly moved in the solvent box without any interaction with the cell membrane. From these results, we conclude that hydrophilic BNO-NS represents a good candidate for DOX molecule transport and stabilization near a cell membrane. In this drug delivery system, the choice of BNO-NS as nanovector is important because it allows delivering an elevated therapeutic dose directly on the cancer cell target without hindrance of the DOX payload.
Fichier principal
Vignette du fichier
Applied Surface Science, 2019, 475, 666-675 .pdf (2.02 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02055616 , version 1 (31-05-2021)

Identifiants

Citer

E. Duverger, Sebastien Balme, Mikhael. Bechelany, Philippe Miele, F. Picaud. Natural payload delivery of the doxorubicin anticancer drug from boron nitride oxide nanosheets. Applied Surface Science, 2019, 475, pp.666-675. ⟨10.1016/j.apsusc.2018.12.273⟩. ⟨hal-02055616⟩
132 Consultations
103 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More