Effect of DEET-multiple exposures on behavior and life history traits in the malaria mosquito Anopheles gambiae (s.s.)

Abstract : Background: Vector-borne diseases are major public health concerns, and their control is threatened by the spread of insecticide resistance in vector populations. In this context, the use of repellents is an alternative approach to limit vector-host interactions. However, prior exposure to repellents is suspected to affect mosquito behavior at the subsequent exposure, possibly reducing the efficacy of the compound. Despite this, the effect of mosquito experience on repellent efficacy remains poorly documented. In the present study, we tested whether a first blood meal successfully obtained upon a DEET-treated net would affect the success at taking a second blood meal in spite of DEET in the malaria mosquito Anopheles gambiae (s.s.). The impact of DEET on mosquito life history traits after the first and the second exposure was also measured, in order to assess the long-term consequences of multiple exposures to DEET in vector insects. Results: A first blood meal obtained upon a DEET-treated net did not influence the success of An. gambiae females to take a second blood meal in spite of DEET. However, data showed that a prior exposure to DEET negatively affected all life history traits tested in this study related to fecundity and fertility. DEET pre-exposed females displayed a reduction in blood engorgement at the second exposure, as well as a reduction in the number of eggs laid and in the proportion of offspring that reach adult stage. Also, an increase of mosquito activity was observed during the second blood meal in DEET-pre-exposed females. Taken together, these data suggest an overall impact of DEET exposure on mosquito fitness. Conclusions: Our results did not evidence any effect of a prior exposure to DEET on its efficacy during the second exposure. However, data show a negative impact of DEET exposure on mosquito fitness. These results give insights to understand the long-term efficacy of the most used mosquito repellent, and highlight that DEET induces deleterious effects on mosquito fitness in addition to repellency, potentially increasing its efficacy for controlling vector-borne diseases.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [38 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-02016650
Contributeur : Philip Agnew <>
Soumis le : mardi 12 février 2019 - 18:30:09
Dernière modification le : vendredi 23 août 2019 - 11:38:03
Document(s) archivé(s) le : lundi 13 mai 2019 - 18:34:47

Fichier

document.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Margaux Mulatier, Ludovic Ahoua Alou, Fabrice Chandre, Cédric Pennetier, Laurent Dormont, et al.. Effect of DEET-multiple exposures on behavior and life history traits in the malaria mosquito Anopheles gambiae (s.s.). Parasites and Vectors, BioMed Central, 2018, 11, pp.432. ⟨10.1186/s13071-018-3024-0⟩. ⟨hal-02016650⟩

Partager

Métriques

Consultations de la notice

102

Téléchargements de fichiers

71