Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans

Abstract : Both Aedes aegytpi and Ae. albopictus are major vectors of 5 important arboviruses (namely chikungunya virus, dengue virus, Rift Valley fever virus, yellow fever virus, and Zika virus), making these mosquitoes an important factor in the worldwide burden of infectious disease. Vector control using insecticides coupled with larval source reduction is critical to control the transmission of these viruses to humans but is threatened by the emergence of insecticide resistance. Here, we review the available evidence for the geographical distribution of insecticide resistance in these 2 major vectors worldwide and map the data collated for the 4 main classes of neurotoxic insecticide (carbamates, organochlorines, organophosphates, and pyrethroids). Emerging resistance to all 4 of these insecticide classes has been detected in the Americas, Africa, and Asia. Target-site mutations and increased insecticide detoxification have both been linked to resistance in Ae. aegypti and Ae. albopictus but more work is required to further elucidate metabolic mechanisms and develop robust diagnostic assays. Geographical distributions are provided for the mechanisms that have been shown to be important to date. Estimating insecticide resistance in unsampled locations is hampered by a lack of standardisation in the diagnostic tools used and by a lack of data in a number of regions for both resistance phenotypes and genotypes. The need for increased sampling using standard methods is critical to tackle the issue of emerging insecticide resistance threatening human health. Specifically, diagnostic doses and well-characterised susceptible strains are needed for the full range of insecticides used to control Ae. aegypti and Ae. albopictus to standardise measurement of the resistant phenotype, and calibrated diagnostic assays are needed for the major mechanisms of resistance.
Liste complète des métadonnées

Littérature citée [65 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-02013555
Contributeur : Hal Mivegec <>
Soumis le : lundi 11 février 2019 - 10:20:45
Dernière modification le : vendredi 16 octobre 2020 - 10:18:02
Archivage à long terme le : : dimanche 12 mai 2019 - 13:38:05

Fichier

journal.pntd.0005625.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Citation

Catherine Moyes, John Vontas, Ademir Martins, Lee Ng, Sin Koou, et al.. Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans. PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (7), pp.e0005625. ⟨10.1371/journal.pntd.0005625⟩. ⟨hal-02013555⟩

Partager

Métriques

Consultations de la notice

204

Téléchargements de fichiers

373