J. Rehm, C. Mathers, S. Popova, M. Thavorncharoensap, Y. Teerawattananon et al., Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders, Lancet, vol.373, pp.60746-60753, 2009.

M. Prince, M. Guerchet, and M. Prina, The Epidemiology and Impact of Dementia: Current State and Future Trends. World Health Organization, 2015.

B. Winblad, P. Amouyel, and S. Andrieu, Defeating Alzheimer's disease and other dementias: a priority for European science and society, Lancet Neurol, vol.15, issue.16, pp.62-66, 2016.

K. J. Anstey, H. A. Mack, and N. Cherbuin, Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies, Am J Geriatr Psychiatry, vol.17, pp.542-55, 2009.

F. Panza, V. Frisardi, and D. Seripa, Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?, Int J Geriatr Psychiatry, vol.27, pp.1218-1256, 2012.

W. Xu, H. Wang, and Y. Wan, Alcohol consumption and dementia risk: a dose-response meta-analysis of prospective studies, Eur J Epidemiol, vol.32, pp.31-42, 2017.

G. Livingston, A. Sommerlad, and V. Orgeta, Dementia prevention, intervention, and care, Lancet, vol.390, issue.17, pp.31363-31369, 2017.

N. Binder, L. Manderscheid, and M. Schumacher, The combined association of alcohol consumption with dementia risk is likely biased due to lacking account of death cases, Eur J Epidemiol, vol.32, pp.627-636, 2017.

K. Leffondré, C. Touraine, C. Helmer, and P. Joly, Interval-censored time-toevent and competing risk with death: is the illness-death model more accurate than the Cox model?, Int J Epidemiol, vol.42, pp.1177-86, 2013.

A. Britton, Y. Ben-shlomo, M. Benzeval, D. Kuh, and S. Bell, Life course trajectories of alcohol consumption in the United Kingdom using longitudinal data from nine cohort studies, BMC Med, vol.13, p.47, 2015.

M. Schwarzinger, B. G. Pollock, O. Hasan, and C. Dufouil, Rehm JQalyDays Study Group. Contribution of alcohol use disorders to the burden of dementia in France 2008-13: a nationwide retrospective cohort study, Lancet Public Health, vol.3, issue.18, pp.30022-30029, 2018.

S. Haseeb, B. Alexander, and A. Baranchuk, Wine and Cardiovascular Health: A Comprehensive Review, Circulation, vol.136, pp.1434-1482, 2017.

A. M. Wood, S. Kaptoge, and A. S. Butterworth, Risk thresholds for alcohol consumption: combined analysis of individualparticipant data for 599 912 current drinkers in 83 prospective studies, Lancet, vol.391, issue.18, p.30134, 2018.

C. Ricci, A. Wood, and D. Muller, Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD casecohort study, BMJ, vol.361, p.934, 2018.

G. J. Biessels, M. W. Strachan, F. L. Visseren, L. J. Kappelle, and R. A. Whitmer, Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions, Lancet Diabetes Endocrinol, vol.2, issue.13, pp.70088-70091, 2014.

M. G. Marmot, G. D. Smith, and S. Stansfeld, Health inequalities among British civil servants: the Whitehall II study, Lancet, vol.337, pp.1387-93, 1991.

, UK Chief Medical Officers. UK Chief Medical Officers' Low Risk Drinking Guidelines, 2016.

B. L. Jones and D. S. Nagin, A Note on a Stata Plugin for Estimating Groupbased Trajectory Models, Sociol Methods Res, vol.42, pp.608-621, 2013.

, See rights and reprints

D. S. Nagin and C. L. Odgers, Group-based trajectory modeling in clinical research, Annu Rev Clin Psychol, vol.6, pp.109-147, 2010.

D. Mayfield, G. Mcleod, and P. Hall, The CAGE questionnaire: validation of a new alcoholism screening instrument, Am J Psychiatry, vol.131, pp.1121-1124, 1974.

J. A. Ewing, Detecting alcoholism. The CAGE questionnaire, JAMA, vol.252, pp.1905-1912, 1984.

, Centers for Disease Control and Prevention. Alcohol and Public Health: Alcohol-Related Disease Impact (ARDI, 2018.

Y. Doyle and A. Bull, Role of private sector in United Kingdom healthcare system, BMJ, vol.321, pp.563-568, 2000.

S. Sabia, A. Dugravot, and J. F. Dartigues, Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study, BMJ, vol.357, 2017.

H. Amieva, L. Goff, M. Millet, and X. , Prodromal Alzheimer's disease: successive emergence of the clinical symptoms, Ann Neurol, vol.64, pp.492-500, 2008.

S. A. Stansfeld and M. G. Marmot, Social class and minor psychiatric disorder in British Civil Servants: a validated screening survey using the General Health Questionnaire, Psychol Med, vol.22, pp.739-788, 1992.

H. Fejr, Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis

N. Orsini and S. Greenland, A procedure to tabulate and plot results after flexible modeling of a quantitative covariate, Stata J, vol.11, pp.1-29, 2011.

C. C. Chang, Y. Zhao, C. W. Lee, and M. Ganguli, Smoking, death, and Alzheimer disease: a case of competing risks, Alzheimer Dis Assoc Disord, vol.26, pp.300-306, 2012.

M. P. Fox, T. L. Lash, and S. Greenland, A method to automate probabilistic sensitivity analyses of misclassified binary variables, Int J Epidemiol, vol.34, pp.1370-1376, 2005.

A. Sommerlad, G. Perera, A. Singh-manoux, G. Lewis, R. Stewart et al., Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy, Alzheimers Dement, 2008.

D. S. Knopman, R. C. Petersen, W. A. Rocca, E. B. Larson, and M. Ganguli, Passive case-finding for Alzheimer's disease and dementia in two U.S. communities, Alzheimers Dement, vol.7, pp.53-60, 2011.

S. Sabia, A. Elbaz, and A. Britton, Alcohol consumption and cognitive decline in early old age, Neurology, vol.82, pp.332-341, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-01148010

T. Anttila, E. L. Helkala, and M. Viitanen, Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study, BMJ, vol.329, p.539, 2004.

T. Järvenpää, J. O. Rinne, M. Koskenvuo, I. Räihä, and J. Kaprio, Binge drinking in midlife and dementia risk, Epidemiology, vol.16, pp.766-71, 2005.

E. P. Handing, R. Andel, P. Kadlecova, M. Gatz, and N. L. Pedersen, Midlife Alcohol Consumption and Risk of Dementia Over 43 Years of FollowUp: A Population-Based Study From the Swedish Twin Registry, J Gerontol A Biol Sci Med Sci, vol.70, pp.1248-54, 2015.

S. E. Brien, P. E. Ronksley, B. J. Turner, K. J. Mukamal, and W. A. Ghali, Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies, BMJ, vol.342, 2011.

M. V. Holmes, C. E. Dale, and L. Zuccolo, InterAct Consortium. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data, BMJ, vol.349, p.4164, 2014.

A. Topiwala, C. L. Allan, and V. Valkanova, Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study, BMJ, vol.357, p.2353, 2017.

W. Zhu, N. D. Volkow, Y. Ma, J. S. Fowler, and G. J. Wang, Relationship between ethanol-induced changes in brain regional metabolism and its motor, behavioural and cognitive effects, Alcohol Alcohol, vol.39, pp.53-61, 2004.

N. M. Zahr, K. L. Kaufman, and C. G. Harper, Clinical and pathological features of alcohol-related brain damage, Nat Rev Neurol, vol.7, pp.284-94, 2011.

F. Panza, C. Capurso, and V. Solfrizzi, Alcohol use, thiamine deficiency, and cognitive impairment, JAMA, vol.299, pp.2853-2857, 2008.

C. Knott, S. Bell, and A. Britton, Alcohol Consumption and the Risk of Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of More Than 1.9 Million Individuals From 38 Observational Studies, Diabetes Care, vol.38, pp.1804-1816, 2015.

P. M. Miller, R. F. Anton, B. M. Egan, J. Basile, and S. A. Nguyen, Excessive alcohol consumption and hypertension: clinical implications of current research, J Clin Hypertens (Greenwich), vol.7, pp.346-51, 2005.

E. Mostofsky, H. S. Chahal, K. J. Mukamal, E. B. Rimm, and M. A. Mittleman, Alcohol and Immediate Risk of Cardiovascular Events: A Systematic Review and Dose-Response MetaAnalysis, Circulation, vol.133, pp.979-87, 2016.

C. Zhang, Y. Y. Qin, and Q. Chen, Alcohol intake and risk of stroke: a dose-response meta-analysis of prospective studies, Int J Cardiol, vol.174, pp.669-77, 2014.

, International allience for responsible drinking, 2018.