E. A. Worthey, S. Martinez-calvillo, A. Schnaufer, G. Aggarwal, J. Cawthra et al., Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene, Nucleic Acids Res, vol.31, issue.14, pp.4201-4211, 2003.

A. C. Ivens, C. S. Peacock, E. A. Worthey, L. Murphy, G. Aggarwal et al., The genome of the kinetoplastid parasite, Leishmania major Science, vol.309, issue.5733, pp.436-478, 2005.

C. E. Clayton, Life without transcriptional control? From fly to man and back again, EMBO J, vol.21, issue.8, pp.1881-1889, 2002.

M. Berriman, E. Ghedin, C. Hertz-fowler, G. Blandin, H. Renauld et al., The genome of the African trypanosome Trypanosoma brucei, Science, vol.309, issue.5733, pp.416-438, 2005.

M. Aslett, C. Aurrecoechea, M. Berriman, J. Brestelli, B. P. Brunk et al., TriTrypDB: a functional genomic resource for the Trypanosomatidae, Nucleic Acids Res, vol.38, pp.457-62, 2010.

F. J. Logan-klumpler, D. Silva, N. Boehme, U. Rogers, M. B. Velarde et al., GeneDB-an annotation database for pathogens, Nucleic Acids Res, vol.40, issue.D1, pp.98-108, 2012.

C. Subramaniam, P. Veazey, S. Redmond, J. Hayes-sinclair, E. Chambers et al., Chromosome-wide analysis of gene function by RNA interference in the african trypanosome, Eukaryot Cell, vol.5, issue.9, pp.1539-1588, 2006.

S. Alsford, D. J. Turner, S. O. Obado, A. Sanchez-flores, L. Glover et al., High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome, Genome Res, vol.21, issue.6, pp.915-939, 2011.

S. Monnerat, C. Clucas, E. Brown, J. C. Mottram, and T. C. Hammarton, Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen, BMC Res Notes, vol.2, p.46, 2009.

M. L. Povelones, C. Tiengwe, E. Gluenz, K. Gull, P. T. Englund et al., Mitochondrial shape and function in trypanosomes requires the outer membrane protein, TbLOK1, Mol Microbiol, vol.87, issue.4, pp.713-742, 2013.

J. C. Morris, Z. Wang, M. E. Drew, and P. T. Englund, Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library, EMBO J, vol.21, issue.17, pp.4429-4467, 2002.

A. Ploubidou, D. R. Robinson, R. C. Docherty, E. O. Ogbadoyi, and K. Gull, Evidence for novel cell cycle checkpoints in trypanosomes: kinetoplast segregation and cytokinesis in the absence of mitosis, J Cell Sci, vol.112, pp.4641-50, 1999.
URL : https://hal.archives-ouvertes.fr/hal-02327347

P. G. Mckean, Coordination of cell cycle and cytokinesis in Trypanosoma brucei, Curr Opin Microbiol, vol.6, issue.6, pp.600-607, 2003.

E. Gluenz, M. L. Povelones, P. T. Englund, and K. Gull, The kinetoplast duplication cycle in Trypanosoma brucei is orchestrated by cytoskeleton-mediated cell morphogenesis, Mol Cell Biol, vol.31, issue.5, pp.1012-1033, 2011.

T. C. Hammarton, S. Monnerat, and J. C. Mottram, Cytokinesis in trypanosomatids, Curr Opin Microbiol, vol.10, issue.6, pp.520-527, 2007.

H. Farr and K. Gull, Cytokinesis in trypanosomes, Cytoskeleton (Hoboken), vol.69, issue.11, pp.931-972, 2012.

A. K. Panigrahi, Y. Ogata, A. Zikova, A. Anupama, R. A. Dalley et al., A comprehensive analysis of Trypanosoma brucei mitochondrial proteome, Proteomics, vol.9, issue.2, pp.434-50, 2009.

X. Zhang, J. Cui, D. Nilsson, K. Gunasekera, A. Chanfon et al., The Trypanosoma brucei MitoCarta and its regulation and splicing pattern during development, Nucleic Acids Res, vol.38, issue.21, pp.7378-87, 2010.

M. Pusnik, I. Small, L. K. Read, T. Fabbro, and A. Schneider, Pentatricopeptide repeat proteins in Trypanosoma brucei function in mitochondrial ribosomes, Mol Cell Biol, vol.27, pp.6876-88, 2007.

H. Hashimi, Z. Cicova, L. Novotna, Y. Z. Wen, and J. Lukes, Kinetoplastid guide RNA biogenesis is dependent on subunits of the mitochondrial RNA binding complex 1 and mitochondrial RNA polymerase, RNA, vol.15, issue.4, pp.588-99, 2009.

S. Desy, A. Schneider, and J. Mani, Trypanosoma brucei has a canonical mitochondrial processing peptidase, Mol Biochem Parasitol, vol.185, issue.2, pp.161-165, 2012.

C. Colasante, V. P. Alibu, S. Kirchberger, J. Tjaden, C. Clayton et al., Characterization and developmentally regulated localization of the mitochondrial carrier protein homologue MCP6 from Trypanosoma brucei, Eukaryot Cell, vol.5, issue.8, pp.1194-205, 2006.

L. Kafkova, M. L. Ammerman, D. Faktorova, J. C. Fisk, S. L. Zimmer et al., Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei, RNA, vol.18, issue.10, pp.1846-61, 2012.

M. L. Ammerman, K. M. Downey, H. Hashimi, J. C. Fisk, D. L. Tomasello et al., Architecture of the trypanosome RNA editing accessory complex, MRB1, Nucleic Acids Res, vol.40, issue.12, pp.5637-50, 2012.

J. Weng, I. Aphasizheva, R. D. Etheridge, L. Huang, X. Wang et al., Guide RNA-binding complex from mitochondria of trypanosomatids, Mol Cell, vol.32, issue.2, pp.198-209, 2008.

A. Zikova, A. K. Panigrahi, A. D. Uboldi, R. A. Dalley, E. Handman et al., Structural and functional association of Trypanosoma brucei MIX protein with cytochrome c oxidase complex, Eukaryot Cell, vol.7, issue.11, pp.1994-2003, 2008.

N. Acestor, A. Zikova, R. A. Dalley, A. Anupama, A. K. Panigrahi et al., Trypanosoma brucei mitochondrial respiratome: composition and organization in procyclic form, Mol Cell Proteomics, vol.10, issue.9, 2011.

I. Subota, B. Rotureau, T. Blisnick, S. Ngwabyt, M. Durand-dubief et al., ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation, Mol Biol Cell, vol.22, issue.22, pp.4205-4224, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-01371322

A. Zikova, A. K. Panigrahi, R. A. Dalley, N. Acestor, A. Anupama et al., Trypanosoma brucei mitochondrial ribosomes: affinity purification and component identification by mass spectrometry, Mol Cell Proteomics, vol.7, issue.7, pp.1286-96, 2008.

M. M. Klingbeil, S. A. Motyka, and P. T. Englund, Multiple mitochondrial DNA polymerases in Trypanosoma brucei, Mol Cell, vol.10, issue.1, pp.175-86, 2002.

Y. Liu, S. A. Motyka, and P. T. Englund, Effects of RNA interference of Trypanosoma brucei structure-specific endonuclease-I on kinetoplast DNA replication, J Biol Chem, vol.280, issue.42, pp.35513-35533, 2005.

B. Liu, H. Molina, D. Kalume, A. Pandey, J. D. Griffith et al., Role of p38 in replication of Trypanosoma brucei kinetoplast DNA, Mol Cell Biol, vol.26, issue.14, pp.5382-93, 2006.

B. Liu, G. Yildirir, J. Wang, G. Tolun, J. D. Griffith et al., TbPIF1, a Trypanosoma brucei mitochondrial DNA helicase, is essential for kinetoplast minicircle replication, J Biol Chem, vol.285, issue.10, pp.7056-66, 2010.

Z. Zhao, M. E. Lindsay, R. Chowdhury, A. Robinson, D. R. Englund et al., p166, a link between the trypanosome mitochondrial DNA and flagellum, mediates genome segregation, Embo J, vol.27, issue.1, pp.143-54, 2008.
URL : https://hal.archives-ouvertes.fr/hal-02323531

K. Beck, N. Acestor, A. Schulfer, A. Anupama, J. Carnes et al., Trypanosoma brucei Tb927.2.6100 is an essential protein associated with kinetoplast DNA, Eukaryot Cell, vol.12, issue.7, pp.970-978, 2013.

C. Benz, C. Clucas, J. C. Mottram, and T. C. Hammarton, Cytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin, PLoS One, vol.7, issue.1, p.30367, 2012.

S. Lacomble, S. Vaughan, C. Gadelha, M. K. Morphew, M. K. Shaw et al., Basal body movements orchestrate membrane organelle division and cell, J Cell Sci, vol.123, pp.2884-91, 2010.

M. Casanova, P. Portalès, C. Blaineau, L. Crobu, P. Bastien et al., Inhibition of active nuclear transport is an intrinsic trigger of programmed cell death in trypanosomatids, Cell Death Differ, vol.15, issue.12, pp.1910-1930, 2008.
URL : https://hal.archives-ouvertes.fr/hal-02049718

E. Wirtz, S. Leal, C. Ochatt, and G. A. Cross, A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei, Mol Biochem Parasitol, vol.99, issue.1, pp.89-101, 1999.

. Trypsproteome,

A. Birmingham, E. M. Anderson, A. Reynolds, D. Ilsley-tyree, D. Leake et al., 3? UTR seed matches, but not overall identity, are associated with RNAi off-targets, Nat Methods, vol.3, issue.3, pp.199-204, 2006.

-. Trypanofan, brucei functional genomics project

S. Redmond, J. Vadivelu, and M. Field, RNAit: an automated web-based tool for the selection of RNAi targets in Trypanosoma brucei, Mol Biochem Parasitol, vol.128, issue.1, pp.115-123, 2003.

D. J. Lacount, B. Barrett, and J. E. Donelson, Trypanosoma brucei FLA1 is required for flagellum attachment and cytokinesis, J Biol Chem, vol.277, issue.20, pp.17580-17588, 2002.

C. Blaineau, M. Tessier, P. Dubessay, L. Tasse, L. Crobu et al., Submit your next manuscript to BioMed Central and take full advantage of: ? Convenient online submission ? Thorough peer review ? No space constraints or color figure charges ? Immediate publication on acceptance ? Inclusion in PubMed, CAS, Scopus and Google Scholar ? Research which is freely available for redistribution, Curr Biol, vol.17, issue.9, pp.778-82, 2007.