, WHO. World Malaria Report, 2016.
Genome sequence of the human malaria parasite Plasmodium falciparum, Nature, vol.419, issue.6906, pp.498-511, 2002. ,
Extreme mutation bias and high AT content in Plasmodium falciparum. Nucleic acids research, p.27994033, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01989279
Homopolymer tract organization in the human malarial parasite Plasmodium falciparum and related Apicomplexan parasites, BMC genomics, vol.15, p.25281558, 2014. ,
Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications, PLoS pathogens, vol.9, issue.5, p.23717205, 2013. ,
Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites, Mol Biol Evol, vol.24, issue.2, pp.562-73, 2007. ,
Multistranded DNA structures. Current opinion in structural biology, vol.9, p.10361092, 1999. ,
Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes, BMC genomics, vol.10, p.362, 2009. ,
Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs, BMC genomics, vol.17, issue.1, p.27809775, 2016. ,
A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites, Nat Commun, vol.5, p.3216, 2014. ,
Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans, Current Biology, vol.18, issue.12, p.18538569, 2008. ,
Antigenic variation and the generation of diversity in malaria parasites, Curr Opin Microbiol, vol.15, issue.4, p.22503815, 2012. ,
Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis, PLoS genetics, vol.10, issue.12, p.25521112, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01989273
Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families, PLoS genetics, vol.9, issue.2, p.23408914, 2013. ,
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes, Cell, vol.82, issue.1, p.7541722, 1995. ,
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes, Cell, vol.82, issue.1, p.7606775, 1995. ,
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes, Cell, vol.82, issue.1, p.7606788, 1995. ,
DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families, Nucleic acids research, vol.42, issue.4, pp.2270-81, 2014. ,
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance, Trends Biochem Sci, vol.33, issue.12, p.18926708, 2008. ,
Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential, Nucleic acids research, vol.38, issue.4, pp.1114-1136, 2010. ,
Characterization of recombinant malarial RecQ DNA helicase, Molecular and biochemical parasitology, vol.196, issue.1, p.25111966, 2014. ,
Genome wide identification of Plasmodium falciparum helicases: a comparison with human host, Cell cycle, vol.9, issue.1, pp.104-124, 2010. ,
Single-molecule analysis reveals that DNA replication dynamics vary across the course of schizogony in the malaria parasite Plasmodium falciparum, Sci Rep, vol.7, issue.1, p.28638076, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01760468
Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes, Cell, vol.170, issue.2, p.28708996, 2017. ,
Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates, BMC genomics, vol.8, p.17286864, 2007. ,
Gene inactivation of Pf11-1 of Plasmodium falciparum by chromosome breakage and healing: identification of a gametocyte-specific protein with a potential role in gametogenesis, The EMBO journal, vol.11, issue.6, p.1600948, 1992. ,
G-quadruplex DNA motifs in the malaria parasite Plasmodium falciparum and their potential as novel antimalarial drug targets, Antimicrobial Agents & Chemotherapy, 2017. ,
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells, Cancer Res, vol.59, issue.3, p.9973212, 1999. ,
Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition, Journal of the American Chemical Society, p.10, 1999. ,
Plasmodium falciparum Bloom homologue, a nucleocytoplasmic protein, translocates in 3' to 5' direction and is essential for parasite growth, Biochimica et biophysica acta, vol.1864, issue.5, p.26917473, 2016. ,
Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites, PloS one, vol.11, issue.4, p.27100094, 2016. ,
SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination, Nat Struct Mol Biol, vol.16, issue.2, pp.159-67, 2009. ,
The Werner syndrome protein: linking the replication checkpoint response to genome stability, Aging (Albany NY), vol.3, issue.3, p.21389352, 2011. ,
Roles of Caenorhabditis elegans WRN Helicase in DNA Damage Responses, and a Comparison with Its Mammalian Homolog: A Mini-Review, Gerontology, vol.62, issue.3, pp.296-303, 2016. ,
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability. The Journal of cell biology, p.29042409, 2017. ,
The Bloom's syndrome gene product promotes branch migration of holliday junctions, Proceedings of the National Academy of Sciences of the United States of America, vol.97, issue.12, p.10823897, 2000. ,
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases, Nucleic acids research, vol.29, issue.13, p.11433031, 2001. ,
The Bloom's syndrome helicase unwinds G4 DNA. The Journal of biological chemistry, vol.273, p.9765292, 1998. ,
WRN regulates pathway choice between classical and alternative non-homologous end joining, Nature communications, vol.7, p.27922005, 2016. ,
Plasmodium falciparum Werner homologue is a nuclear protein and its biochemical activities reside in the N-terminal region, Protoplasma, vol.253, issue.1, p.25824666, 2016. ,
Visualization of altered replication dynamics after DNA damage in human cells, The Journal of biological chemistry, vol.279, p.14982920, 2004. ,
Plasmodium telomeric sequences: structure, stability and quadruplex targeting by small compounds, Chembiochem, vol.9, issue.16, p.18924216, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00339356
NSR-seq transcriptional profiling enables identification of a gene signature of Plasmodium falciparum parasites infecting children, J Clin Invest, vol.121, issue.3, pp.1119-1148, 2011. ,
Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites, Cell host & microbe, vol.5, issue.2, pp.179-90, 2009. ,
Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription, Cell, vol.63, issue.4, p.2225075, 1990. ,
Potent inhibitors of telomerase activity and cell proliferation in Plasmodium falciparum, Molecular and biochemical parasitology, vol.207, issue.1, p.27217226, 2016. ,
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2, Molecular cell, vol.14, issue.6, p.15200954, 2004. ,
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity, Science, vol.306, issue.5703, p.15591207, 2004. ,
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum, Cell, vol.121, issue.1, p.15820675, 2005. ,
The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes, International journal for parasitology, vol.40, issue.1, pp.35-43, 2010. ,
Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains, PloS one, vol.10, issue.3, p.25780929, 2015. ,
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin, Nature, vol.452, issue.7186, pp.492-498, 2008. ,
Human malaria parasites in continuous culture, Science, vol.193, issue.4254, p.781840, 1976. ,
Synchronization of Plasmodium falciparum erythrocytic stages in culture, J Parasitol, vol.65, issue.3, p.383936, 1979. ,
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination, International journal for parasitology, vol.32, issue.1, p.11796125, 2002. ,
Transformation of malaria parasites by the spontaneous uptake and expression of DNA from human erythrocytes, Nucleic acids research, vol.29, issue.3, p.11160909, 2001. ,
Plasmodium falciparum telomerase: de novo telomere addition to telomeric and nontelomeric sequences and role in chromosome healing, Molecular and cellular biology, vol.18, issue.2, p.9447988, 1998. ,
A simple RNA analysis method shows var and rif multigene family expression patterns in Plasmodium falciparum, Molecular and biochemical parasitology, vol.105, issue.2, p.10693754, 2000. ,
Variable switching rates of malaria virulence genes are associated with chromosomal position. Molecular microbiology, vol.64, p.17555435, 2007. ,
Simple and inexpensive fluorescencebased technique for high-throughput antimalarial drug screening. Antimicrobial agents and chemotherapy, vol.48, p.15105138, 2004. ,
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing, Nature, vol.487, issue.7407, pp.375-384, 2012. ,
Savant: genome browser for high-throughput sequencing data, Bioinformatics, vol.26, issue.16, pp.1938-1982, 2010. ,
Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomes, Nature methods, vol.6, issue.4, pp.291-296, 2009. ,
TopHat: discovering splice junctions with RNA-Seq, Bioinformatics, vol.25, issue.9, pp.1105-1116, 2009. ,
HTSeq-a Python framework to work with high-throughput sequencing data, Bioinformatics, vol.31, issue.2, pp.166-175, 2015. ,
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation, Nat Biotechnol, vol.28, issue.5, p.20436464, 2010. ,
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data, Bioinformatics, vol.26, issue.1, pp.139-179, 2010. ,
Artemis: sequence visualization and annotation, Bioinformatics, vol.16, issue.10, p.11120685, 2000. ,
Tandem repeats finder: a program to analyze DNA sequences, Nucleic acids research, vol.27, issue.2, p.9862982, 1999. ,
WindowMasker: window-based masker for sequenced genomes, Bioinformatics, vol.22, issue.2, pp.134-175, 2006. ,
Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing, Methods, vol.57, issue.2, p.22579803, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00733285
Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum, Malar J, vol.14, issue.490, 2015. ,
The cellular and molecular basis for malaria parasite invasion of the human red blood cell, The Journal of cell biology, vol.198, issue.6, p.22986493, 2012. ,
The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum, PLoS biology, vol.1, issue.1, p.12929205, 2003. ,
PlasmoDB: a functional genomic database for malaria parasites, Nucleic acids research, vol.37, pp.539-582, 2009. ,