Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM)

Abstract : BACKGROUND: Placenta-mediated pregnancy complications include pre-eclampsia, late pregnancy loss, placental abruption, and the small-for-gestational age newborn. They are leading causes of maternal, fetal, and neonatal morbidity and mortality in developed nations. Women who have experienced these complications are at an elevated risk of recurrence in subsequent pregnancies. However, despite decades of research no effective strategies to prevent recurrence have been identified, until recently. We completed a pooled summary-based meta-analysis that strongly suggests that low-molecular-weight heparin reduces the risk of recurrent placenta-mediated complications. The proposed individual patient data meta-analysis builds on this successful collaboration. The project is called AFFIRM, An individual patient data meta-analysis oF low-molecular-weight heparin For prevention of placenta-medIated pRegnancy coMplications. METHODS/DESIGN: We conducted a systematic review to identify randomized controlled trials with a low-molecular-weight heparin intervention for the prevention of recurrent placenta-mediated pregnancy complications. Investigators and statisticians representing eight trials met to discuss the outcomes and analysis plan for an individual patient data meta-analysis. An additional trial has since been added for a total of nine eligible trials. The primary analyses from the original trials will be replicated for quality assurance prior to recoding the data from each trial and combining it into a common dataset for analysis. Using the anonymized combined data we will conduct logistic regression and subgroup analyses aimed at identifying which women with previous pregnancy complications benefit most from treatment with low-molecular-weight heparin during pregnancy. DISCUSSION: The goal of the proposed individual patient data meta-analysis is a thorough estimation of treatment effects in patients with prior individual placenta-mediated pregnancy complications and exploration of which complications are specifically prevented by low-molecular-weight heparin. SYSTEMATIC REVIEW REGISTRATION: PROSPERO (International Prospective Registry of Systematic Reviews) 23 December 2013, CRD42013006249.
Liste complète des métadonnées

Littérature citée [51 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-01945886
Contributeur : Anthony Herrada <>
Soumis le : mercredi 5 décembre 2018 - 15:52:02
Dernière modification le : vendredi 12 juin 2020 - 16:58:21
Archivage à long terme le : : mercredi 6 mars 2019 - 15:16:23

Fichier

document-2.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Marc Rodger, Nicole Langlois, Johanna Ip de Vries, Evelyne Rey, Jean-Christophe Gris, et al.. Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM). Systematic Reviews, BioMed Central, 2014, 3, pp.69. ⟨10.1186/2046-4053-3-69⟩. ⟨hal-01945886⟩

Partager

Métriques

Consultations de la notice

97

Téléchargements de fichiers

240