Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Impact of anatomical location of lower limb venous thrombus on the risk of subsequent cancer

Abstract : After a proximal deep-vein thrombosis (P-DVT), the risk of diagnosis of a previously unsuspected cancer is high. Isolated distal DVT (iD-DVT; i.e. infra-popliteal DVT without pulmonary embolism [PE]) and isolated superficial-vein thrombosis (iSVT; i.e. without concomitant DVT and PE) are at least as frequent as P-DVT but their association with subsequent cancer is uncertain. We exploited data from the OPTIMEV prospective, observational, multicentre study to i) compare the risk of subsequent cancer three years after a first objectively confirmed iSVT, iD-DVT and iP-DVT in patients without a prior history of cancer or of venous thromboembolism, ii) assess predictors of subsequent cancer in cases of iD-DVT. The overall cumulative rates of cancer among the 304 patients with iSVT, 536 patients with iD-DVT, and 327 patients with iP-DVT were similar (3.4% 95% confidence interval [1.8-6.2], 3.9% [2.5-5.9] and 3.9% [2.3-6.8], respectively), regardless of whether the index venous thromboembolic event was unprovoked or associated with a major transient risk factor. Neither anatomical (muscular vs deep-calf DVT) nor ultrasound scan characteristics (number of thrombosed veins, clot diameter under compression) seemed strongly associated with the risk of cancer in cases of iD-DVT. In patients managed in routine practice, all the different clinical expressions of lower limb venous thromboembolism are associated with a similar risk of subsequent cancer. From a clinical practice point of view, this suggests that cancer screening, without discussing the necessity, or not, of such screening, should not differ between a deep-proximal, deep-distal or superficial location of thrombosis.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Anthony Herrada <>
Soumis le : mercredi 5 décembre 2018 - 14:11:15
Dernière modification le : mercredi 23 décembre 2020 - 10:26:22




Jean-Philippe Galanaud, Anne Cécile Arnoult, Marie-Antoinette Sevestre, Céline Genty, Michael Bonaldi, et al.. Impact of anatomical location of lower limb venous thrombus on the risk of subsequent cancer. Thrombosis and Haemostasis, Schattauer, 2014, 112 (6), pp.1129-1136. ⟨10.1160/TH14-04-0351⟩. ⟨hal-01945667⟩



Consultations de la notice