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Article Dans Une Revue Annals of Clinical and Translational Neurology Année : 2015

GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder

Ziv Gan-Or
Anat Mirelman
  • Fonction : Auteur
Isabelle Arnulf
Anat Bar-Shira
  • Fonction : Auteur
Alex Desautels
Claire S. Leblond
  • Fonction : Auteur
Birgit Frauscher
  • Fonction : Auteur
Roy Alcalay
  • Fonction : Auteur
Rachel Saunders-Pullman
  • Fonction : Auteur
Karen S. Marder
  • Fonction : Auteur
Patrick A. Dion
  • Fonction : Auteur
  • PersonId : 938784
Nir Giladi
  • Fonction : Auteur
Guy A. Rouleau
  • Fonction : Auteur
  • PersonId : 889825

Résumé

Rapid eye movement sleep behavior disorder and GBA mutations are both associated with Parkinson's disease. The GBA gene was sequenced in idiopathic rapid eye movement sleep behavior disorder patients (n = 265), and compared to controls (n = 2240). Rapid eye movement sleep behavior disorder questionnaire was performed in an independent Parkinson's disease cohort (n = 120). GBA mutations carriers had an OR of 6.24 (10.2% in patients vs. 1.8% in controls, P < 0.0001) for rapid eye movement sleep behavior disorder, and among Parkinson's disease patients, the OR for mutation carriers to have probable rapid eye movement sleep behavior disorder was 3.13 (P = 0.039). These results demonstrate that rapid eye movement sleep behavior disorder is associated with GBA mutations, and that combining genetic and prodromal data may assist in identifying individuals susceptible to Parkinson's disease.

Dates et versions

hal-01945589 , version 1 (05-12-2018)

Identifiants

Citer

Ziv Gan-Or, Anat Mirelman, Ronald B. Postuma, Isabelle Arnulf, Anat Bar-Shira, et al.. GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder. Annals of Clinical and Translational Neurology, 2015, 2 (9), pp.941-945. ⟨10.1002/acn3.228⟩. ⟨hal-01945589⟩
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