B cell-derived cytokines in disease.

Abstract : B cells regulate immune responses during infectious, inflammatory and autoimmune diseases. Beside their unique and characteristic antibody production, B lymphocytes can modulate physiological and pathological processes by presenting antigens or synthesizing signaling molecules. In human and mouse diseases, immuno-intervention, targeting B cells, has revealed and highlighted their antibody-independent regulatory contribution. In this review, we focus on B cell-cytokine production, which is commonly disturbed in inflammatory disorders, and describe the B cell cytokine profile in different diseases. Finally, we discuss some key issues for future B cell-targeted therapies.
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https://hal.umontpellier.fr/hal-01935966
Contributeur : Laurianne Adin <>
Soumis le : mardi 27 novembre 2018 - 10:53:23
Dernière modification le : mardi 28 mai 2019 - 10:38:04

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Moustafa Hamze, Caroline Desmetz, Paul Guglielmi. B cell-derived cytokines in disease.. European Cytokine Network, John Libbey Eurotext, 2013, pp.20-6. ⟨10.1684/ecn.2013.0327⟩. ⟨hal-01935966⟩

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