S. , B. Cmod, A. , A. P. Sr, J. et al., University of Gothenburg, Gothenburg, Sweden; and the Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences (BD), Contributors to the Simons VIP Consortium include the following: Hanalore Alupay

B. Sonia, H. Institut-de-génétique-médicale, . Jeanne-de-flandre, . Lille, . France;-boute et al., Hôpital Pellegrin, France; Doco-Fenzy Martine, Service de Génétique et Biologie de la Reproduction, Centre Hospitalier Bretagne Atlantique CH Chubert, p.7

. Floor-borough, . Wing, . Guy's-hospital, &. Guy's-&-st-thomas, . Nhs-foundation-trust et al., Maladies Rares et Médecine Personnalisée, service de génétique clinique, Unité Inserm U1183

L. Didier, C. Service-de-génétique-médicale, -. De-bordeaux, F. Pellegrin, and . Sébastien, Pediatric Neurology Unit

. Mathieu-dramart-michèle, . Service-de-génétique, . Clinique, F. Chu-amiens-picardie, . Sandra et al.,

K. ;. Pilekaer-sørensen, F. Gh-pellegrin, and . Massimiliano, Service de génétique clinique, Autism spectrum disorders: Neuroimaging findings from systematic reviews, vol.34, pp.28-33, 2017.

B. F. Sparks, S. D. Friedman, D. W. Shaw, E. H. Aylward, D. Echelard et al., Brain structural abnormalities in young children with autism spectrum disorder, Neurology, vol.59, pp.184-192, 2002.

E. Courchesne, K. Pierce, C. M. Schumann, E. Redcay, J. A. Buckwalter et al., Mapping early brain development in autism, vol.56, pp.399-413, 2007.

H. C. Hazlett, H. Gu, B. C. Munsell, S. H. Kim, M. Styner et al., Early brain development in infants at high risk for autism spectrum disorder, Nature, vol.542, pp.348-351, 2017.

A. C. Stanfield, A. M. Mcintosh, M. D. Spencer, R. Philip, S. Gaur et al., Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies, Eur Psychiatry, vol.23, pp.289-299, 2008.

J. Ellegood, E. Anagnostou, B. A. Babineau, J. N. Crawley, L. Lin et al., Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity, Mol Psychiatry, vol.20, pp.118-125, 2014.

D. G. Amaral, The promise and the pitfalls of autism research: An introductory note for new autism researchers, Brain Res, vol.1380, pp.3-9, 2011.

D. G. Amaral, C. M. Schumann, and C. W. Nordahl, Neuroanatomy of autism, vol.31, pp.137-145, 2008.

B. Franke, S. Ripke, V. Anttila, D. P. Hibar, K. Van-hulzen et al., Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept, Nat Neurosci, vol.19, pp.420-431, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01382569

F. Zufferey, E. H. Sherr, N. D. Beckmann, E. Hanson, A. M. Maillard et al., A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders, J Med Genet, vol.49, pp.660-668, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01120401

L. A. Weiss, Y. Shen, J. M. Korn, D. E. Arking, D. T. Miller et al., Association between microdeletion and microduplication at 16p11.2 and autism, N Engl J Med, vol.358, pp.667-675, 2008.

S. J. Sanders, X. He, A. J. Willsey, A. G. Ercan-sencicek, K. E. Samocha et al., Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci, Neuron, vol.87, pp.1215-1233, 2015.

D. Angelo, D. Lebon, S. Chen, Q. Martin-brevet, S. Snyder et al., Defining the effect of the 16p11.2 duplication on cognition, behavior, and medical comorbidities, JAMA Psychiatry, vol.73, pp.20-31, 2016.

E. Hanson, R. Bernier, K. Porche, F. I. Jackson, R. P. Goin-kochel et al., The Cognitive and behavioral phenotype of the 16p11.2 deletion in a clinically ascertained population, Biol Psychiatry, vol.77, pp.785-793, 2015.

A. Moreno-de-luca, D. W. Evans, K. B. Boomer, E. Hanson, R. Bernier et al., The role of parental cognitive, behavioral, and motor profiles in clinical variability in individuals with chromosome 16p11.2 deletions, JAMA Psychiatry, vol.72, pp.119-127, 2015.

S. E. Mccarthy, V. Makarov, G. Kirov, A. M. Addington, J. Mcclellan et al., Microduplications of 16p11.2 are associated with schizophrenia, Nat Genet, vol.41, pp.1223-1227, 2009.

C. R. Marshall, D. P. Howrigan, D. Merico, B. Thiruvahindrapuram, W. Wu et al., Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects, Nat Genet, vol.49, pp.27-35, 2016.

L. Hippolyte, A. M. Maillard, B. Rodriguez-herreros, A. Pain, S. Martinbrevet et al., The number of genomic copies at the 16p11.2 locus modulates language, verbal memory, and inhibition, Biol Psychiatry, vol.80, pp.129-139, 2016.

S. Jacquemont, A. Reymond, F. Zufferey, L. Harewood, R. G. Walters et al., Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus, Nature, vol.478, pp.97-102, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00619240

A. M. Maillard, A. Ruef, F. Pizzagalli, E. Migliavacca, L. Hippolyte et al., The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity, Mol Psychiatry, vol.20, pp.140-147, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01870357

A. Y. Qureshi, S. Mueller, A. Z. Snyder, P. Mukherjee, J. I. Berman et al., Opposing brain differences in 16p11.2 deletion and duplication carriers, J Neurosci, vol.34, pp.11199-11211, 2014.

V. Simons and . Consortium, Simons Variation in Individuals Project (Simons VIP): A genetics-first approach to studying autism spectrum and related neurodevelopmental disorders, Neuron, vol.73, pp.1063-1067, 2012.

D. Wechsler, WPPSI-III Echelle d'intelligence pour la période pré-scolaire et primaire: Troisiéme édition, 2004.

D. Wechsler, WISC-IV Échelle d'intelligence de Wechsler pour enfants: WISC-IV, 2005.

D. Wechsler, WAIS III Echelle d'intelligence pour adultes, 2008.

, Effects of 16p11.2 Copy Number Variants on Neuroanatomy Biological Psychiatry, vol.84, pp.253-264, 2018.

D. Wechsler, Wechsler Abbreviated Scale of Intelligence, 1999.

C. D. Elliott, Differential Abilities Scale-2nd Edition (DAS-II), 2006.

M. Korkman, S. L. Kemp, and U. Kirk, Nepsy, Bilan Neuropsychologique de l'enfant: Manuel. Paris: ECPA, les Éditions du Centre de Psychologie Appliquée, 2008.

R. K. Wagner, J. K. Torgesen, and C. A. Rashotte, Comprehensive Test of Phonological Processes (CTOPP), 1999.

J. N. Constantino, The Social Responsiveness Scale. Los Angeles: Western Psychological Services, 2002.

, Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association, 2013.

B. Fischl, D. H. Salat, E. Busa, M. Albert, M. Dieterich et al., Whole brain segmentation: Neurotechnique automated labeling of neuroanatomical structures in the human brain, Neuron, vol.33, pp.341-355, 2002.

B. Fischl and A. M. Dale, Measuring the thickness of the human cerebral cortex from magnetic resonance images, Proc Natl Acad Sci U S A, vol.97, pp.11050-11055, 2000.

R. L. Buckner, D. Head, J. Parker, A. F. Fotenos, D. Marcus et al., A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlasbased head size normalization: Reliability and validation against manual measurement of total intracranial volume, Neuroimage, vol.23, pp.724-738, 2004.

J. Ashburner and K. J. Friston, Unified segmentation, Neuroimage, vol.26, pp.839-851, 2005.

S. Lorio, S. Fresard, S. Adaszewski, F. Kherif, R. Chowdhury et al., New tissue priors for improved automated classification of subcortical brain structures on MRI, Neuroimage, vol.130, pp.157-166, 2016.

J. Ashburner, A fast diffeomorphic image registration algorithm, Neuroimage, vol.38, pp.95-113, 2007.

J. Ashburner and K. J. Friston, Voxel-based morphometry-The methods, Neuroimage, vol.11, pp.805-821, 2000.

K. J. Friston, A. P. Holmes, K. J. Worsley, J. P. Poline, C. D. Frith et al., Statistical parametric maps in functional imaging: A general linear approach, Hum Brain Mapp, vol.2, pp.189-210, 1994.

K. J. Worsley, An improved theoretical P value for SPMs based on discrete local maxima, Neuroimage, vol.28, pp.1056-1062, 2005.

C. R. Genovese, N. A. Lazar, and T. Nichols, Thresholding of statistical maps in functional neuroimaging using the false discovery rate, Neuroimage, vol.15, pp.870-878, 2002.

R. Toro, M. Perron, B. Pike, L. Richer, S. Veillette et al., Brain size and folding of the human cerebral cortex, Cereb Cortex, vol.18, pp.2352-2357, 2008.

M. Goodkind, S. B. Eickhoff, D. J. Oathes, Y. Jiang, A. Chang et al., Identification of a common neurobiological substrate for mental illness, JAMA Psychiatry, vol.72, pp.305-323, 2015.

H. Namkung, S. Kim, and A. Sawa, The insula: An underestimated brain area in clinical neuroscience, psychiatry, and neurology, Trends Neurosci, vol.40, pp.200-207, 2017.

C. S. Carter, C. E. Bearden, E. T. Bullmore, D. H. Geschwind, D. C. Glahn et al., Enhancing the informativeness and replicability of imaging genomics studies, Biol Psychiatry, vol.82, pp.157-164, 2017.

D. J. Weiner, E. M. Wigdor, S. Ripke, R. K. Walters, J. A. Kosmicki et al., Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders, Nat Genet, vol.450, pp.86-50, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01546155

P. Fusar-poli, J. Radua, P. Mcguire, and S. Borgwardt, Neuroanatomical maps of psychosis onset: Voxel-wise meta-analysis of antipsychotic-naive VBM studies, Schizophr Bull, vol.38, pp.1297-1307, 2012.

A. E. Nordsletten, H. Larsson, J. J. Crowley, C. Almqvist, P. Lichtenstein et al., Patterns of nonrandom mating within and across 11 major psychiatric disorders, JAMA Psychiatry, vol.73, pp.354-356, 2016.

E. Chow, A. Ho, C. Wei, E. Voormolen, A. P. Crawley et al., Association of schizophrenia in 22q11.2 deletion syndrome and gray matter volumetric deficits in the superior temporal gyrus, Am J Psychiatry, vol.168, pp.522-529, 2011.

M. Jalbrzikowski, J. R. Senturk, D. Patel, A. Chow, C. Green et al., Structural abnormalities in cortical volume, thickness, and surface area in 22q11.2 microdeletion syndrome: Relationship with psychotic symptoms, Neuroimage Clin, vol.3, pp.405-415, 2013.

J. E. Schmitt, S. Vandekar, J. Yi, M. E. Calkins, K. Ruparel et al., Aberrant cortical morphometry in the 22q11.2 deletion syndrome, Biol Psychiatry, vol.78, pp.135-143, 2015.

A. Meyer-lindenberg, C. B. Mervis, and K. F. Berman, Neural mechanisms in Williams syndrome: A unique window to genetic influences on cognition and behaviour, Nat Rev Neurosci, vol.7, pp.380-393, 2006.

A. L. Reiss, An experiment of nature: Brain anatomy parallels cognition and behavior in Williams syndrome, J Neurosci, vol.24, pp.5009-5015, 2004.

T. Portmann, M. Yang, R. Mao, G. Panagiotakos, J. Ellegood et al., Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome, Cell Rep, vol.7, pp.1077-1092, 2014.

J. Ellegood and J. N. Crawley, Behavioral and neuroanatomical phenotypes in mouse models of autism, Neurotherapeutics, vol.12, pp.521-533, 2015.

, Effects of 16p11.2 Copy Number Variants on Neuroanatomy