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 Human induced pluripotent stem cells: A disruptive innovation John de Vos 4d4af9f484f0176faf4839d39a2ef64e inserm.fr john-de-vos 21972 3864-21972 http://www.researcherid.com/rid/A-5703-2010 https://orcid.org/0000-0003-1880-4130 https://scholar.google.fr/citations?user=UwHnu5sAAAAJ&hl=fr https://www.idref.fr/060590254 http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-5703-2010 J. Bouckenheimer 1398974-0 C. Sansac 1398975-0 J.-M. Lemaître 1398976-0 Said Assou fc5bf6cfffb1575b5fadf5688af20dc9 inserm.fr said-assou 21355 40260-21355 https://orcid.org/0000-0001-6448-7995 https://www.idref.fr/077205898 Alexandre Philips 4301e58b8657d22572f9313bb8cd857f inserm.fr Supported by grants from the Agence nationale de la recherche (INGESTEM), the association ‘‘Gueules cassées’’ and the UniversityHospital of Montpellier (AOI 2013-A00892-43). 2018-07-16 13:10:45 2024-09-11 20:12:12 2018-07-16 13:10:45 2016-04 contributor Alexandre Philips 4301e58b8657d22572f9313bb8cd857f inserm.fr CCSD hal-01840116 https://hal.umontpellier.fr/hal-01840116 devos:hal-01840116 <i>Current Research in Translational Medicine</i>, 2016, 64 (2), pp.91 - 96. <a target="_blank" href="https://dx.doi.org/10.1016/j.retram.2016.04.001">&#x27E8;10.1016/j.retram.2016.04.001&#x27E9;</a> Current Research in Translational Medicine, 2016, 64 (2), pp.91 - 96. &#x27E8;10.1016/j.retram.2016.04.001&#x27E9; Biologie-Santé Université de Montpellier ANR Université de Montpellier (2015-2021) International No Yes Human induced pluripotent stem cells: A disruptive innovation John de Vos 4d4af9f484f0176faf4839d39a2ef64e inserm.fr john-de-vos 21972 3864-21972 http://www.researcherid.com/rid/A-5703-2010 https://orcid.org/0000-0003-1880-4130 https://scholar.google.fr/citations?user=UwHnu5sAAAAJ&hl=fr https://www.idref.fr/060590254 http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-5703-2010 J. Bouckenheimer 1398974-0 C. Sansac 1398975-0 J.-M. Lemaître 1398976-0 Said Assou fc5bf6cfffb1575b5fadf5688af20dc9 inserm.fr said-assou 21355 40260-21355 https://orcid.org/0000-0001-6448-7995 https://www.idref.fr/077205898 124491 2452-3186 Current Research in Translational Medicine Elsevier-Masson SAS 64 2 91 - 96 2016-04 2016-04 10.1016/j.retram.2016.04.001 27316392 English Pluripotency Regenerative medicine Stem cells Trans-differentiation. Induced pluripotent stem cells Cell reprogramming Life Sciences [q-bio] Journal articles Journal articles Journal articles

This year (2016) will mark the 10th anniversary of the discovery of induced pluripotent stem cells (iPSCs). The finding that the transient expression of four transcription factors can radically remodel the epigenome, transcriptome and metabolome of differentiated cells and reprogram them into pluripotent stem cells has been a major and groundbreaking technological innovation. In this review, we discuss the major applications of this technology that we have grouped in nine categories: a model to study cell fate control; a model to study pluripotency; a model to study human development; a model to study human tissue and organ physiology; a model to study genetic diseases in a dish; a tool for cell rejuvenation; a source of cells for drug screening; a source of cells for regenerative medicine; a tool for the production of human organs in animals.

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