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Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury
Abstract : Mitochondria are crucial organelles that not only regulate the energy metabolism, but also the survival and fate of eukaryotic cells. Mitochondria were recently discovered to be able to translocate from one cell to the other. This phenomenon was observed in vitro and in vivo, both in physiological and pathophysiological conditions including tissue injury and cancer. Mitochondria trafficking was found to exert prominent biological functions. In particular, several studies pointed out that this process governs some of the therapeutic effects of mesenchymal stem cells (MSCs). In this review, we give an overview of the current knowledge on MSC-dependent intercellular mitochondria trafficking and further discuss the recent findings on the intercellular mitochondria transfer between differentiated and mesenchymal stem cells, their biological significance and the mechanisms underlying this process.
https://www.hal.inserm.fr/inserm-01855876
Contributeur : Marie-Luce Vignais <>
Soumis le : mercredi 8 août 2018 - 17:09:29
Dernière modification le : lundi 12 octobre 2020 - 10:28:19
Contributeur : Marie-Luce Vignais <>
Soumis le : mercredi 8 août 2018 - 17:09:29
Dernière modification le : lundi 12 octobre 2020 - 10:28:19
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