Isolated ventricular non-compaction of the myocardium in adults, Heart, vol.93, issue.1, p.16670098, 2007. ,
Left ventricular noncompaction cardiomyopathy: cardiac, neuromuscular, and genetic factors, Nat Rev Cardiol, vol.14, issue.4, p.28079110, 2017. ,
DOI : 10.1038/nrcardio.2016.207
Left ventricular non-compaction cardiomyopathy, Lancet, vol.386, issue.9995, p.25865865, 2015. ,
Mutations in sarcomere protein genes in left ventricular noncompaction, Circulation, vol.117, issue.22, p.18506004, 2008. ,
Ion channel dysfunction associated with arrhythmia, ventricular noncompaction, and mitral valve prolapse: a new overlapping phenotype, J Am Coll Cardiol, vol.64, issue.8, p.25145519, 2014. ,
DOI : 10.1016/j.jacc.2014.06.1154
URL : https://doi.org/10.1016/j.jacc.2014.06.1154
Left ventricular hypertrabeculation/noncompaction and association with additional cardiac abnormalities and neuromuscular disorders, Am J Cardiol, vol.90, issue.8, p.12372586, 2002. ,
The morphological spectrum of ventricular noncompaction, Cardiol Young, vol.15, issue.4, pp.345-64, 2005. ,
A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation, Circ Cardiovasc Genet, vol.7, issue.4, p.4140955, 2014. ,
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy, Nat Med, vol.19, issue.2, p.23314057, 2013. ,
Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block, Cell, vol.117, issue.3, p.15109497, 2004. ,
Molecular mechanism of ventricular trabeculation/compaction and the pathogenesis of the left ventricular noncompaction cardiomyopathy (LVNC), Am J Med Genet C Semin Med Genet, vol.163, issue.3, p.3725649, 2013. ,
Trabeculation in the embryonic heart, Bioessays, vol.18, issue.7, p.8757939, 1996. ,
DOI : 10.1002/bies.950180714
Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation, Am J Med Genet C Semin Med Genet, vol.163, issue.3, p.3723796, 2013. ,
DOI : 10.1002/ajmg.c.31366
URL : http://europepmc.org/articles/pmc3723796?pdf=render
Key Questions Relating to Left Ventricular Noncompaction Cardiomyopathy: Is the Emperor Still Wearing Any Clothes? Can J Cardiol, vol.33, p.28395867, 2017. ,
Establishment of the mouse ventricular conduction system, Cardiovasc Res, vol.91, issue.2, pp.232-274, 2011. ,
Biphasic development of the mammalian ventricular conduction system, Circ Res, vol.107, issue.1, p.20466980, 2010. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01572048
Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans, Novartis Found Symp, vol.250, p.12956333, 2003. ,
A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5, Cold Spring Harb Symp Quant Biol, vol.67, p.12858555, 2002. ,
5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system, Dev Biol, vol.303, issue.2, p.17250822, 2007. ,
Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy, Circ Cardiovasc Genet, vol.6, issue.3, p.3816146, 2013. ,
Inducible Cx40-Cre expression in the cardiac conduction system and arterial endothelial cells, Genesis, vol.49, issue.2, p.21344610, 2011. ,
A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels, Differentiation, vol.91, issue.1-3, p.26897459, 2016. ,
Endothelial plasticity drives arterial remodeling within the endocardium after myocardial infarction, Circ Res, vol.116, issue.11, p.25834185, 2015. ,
DOI : 10.1161/circresaha.116.306476
URL : https://hal.archives-ouvertes.fr/hal-01763859
Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart, Science, vol.345, issue.6192, p.24994653, 2014. ,
Contactin-2 expression in the cardiac Purkinje fiber network, Circ Arrhythm Electrophysiol, vol.3, issue.2, p.3068837, 2010. ,
A computational tool for quantitative analysis of vascular networks, PLoS One, vol.6, issue.11, p.3217985, 2011. ,
Wheat germ agglutinin staining as a suitable method for detection and quantification of fibrosis in cardiac tissue after myocardial infarction, Eur J Histochem, vol.58, issue.4, p.4289847, 2014. ,
Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system, J Clin Invest, vol.113, issue.8, pp.1130-1137, 2004. ,
Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo, Development, vol.132, issue.9, p.15788460, 2005. ,
Pathomorphologic findings in left ventricular hypertrabeculation/noncompaction of adults in relation to neuromuscular disorders, Int J Cardiol, vol.169, issue.4, p.24182672, 2013. ,
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects, Circ Res, vol.103, issue.6, p.2590500, 2008. ,
Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation, Cardiovasc Res, vol.91, issue.2, pp.289-99, 2011. ,
, Epub, p.3125071
Assessment of nonischemic myocardial fibrosis, J Am Coll Cardiol, vol.56, issue.2, p.20620723, 2010. ,
ECG morphology of premature ventricular contractions predicts the presence of myocardial fibrotic substrate on cardiac magnetic resonance imaging in patients undergoing ablation, J Cardiovasc Electrophysiol, vol.28, issue.11, p.28791747, 2017. ,
Left ventricular geometry as a major determinant of left ventricular ejection fraction: physiological considerations and clinical implications, Eur J Heart Fail, p.29105899, 2017. ,
DOI : 10.1002/ejhf.1055
Identification of a hybrid myocardial zone in the mammalian heart after birth, Nat Commun, vol.8, issue.1, p.5519540, 2017. ,
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis, Nat Genet, vol.44, issue.3, p.3288669, 2012. ,
Polycomb repressive complex 2 regulates normal development of the mouse heart, Circ Res, vol.110, issue.3, p.3282145, 2012. ,
Left ventricular twist in left ventricular noncompaction, Eur Heart J Cardiovasc Imaging, vol.15, issue.1, pp.48-55, 2014. ,
DOI : 10.1093/ehjci/jet076
URL : https://academic.oup.com/ehjcimaging/article-pdf/15/1/48/7139303/jet076.pdf
Nkx2-5 suppresses the proliferation of atrial myocytes and conduction system, Circ Res, vol.114, issue.7, p.24563458, 2014. ,
Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation, Lab Invest, vol.89, issue.9, p.2733927, 2009. ,
Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation, Cardiovasc Res, 2010. ,
DOI : 10.1093/cvr/cvq009
URL : https://academic.oup.com/cardiovascres/article-pdf/86/3/452/17199188/cvq009.pdf
, , vol.86, 20083571.
SCN5A variants in Japanese patients with left ventricular noncompaction and arrhythmia, Mol Genet Metab, vol.93, issue.4, pp.468-74, 2008. ,
Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction, Europace, vol.16, issue.11, pp.1646-54, 2014. ,
Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function, J Am Heart Assoc, vol.4, issue.1, p.4330051, 2015. ,
Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction, J Am Coll Cardiol, vol.39, issue.3, p.11823083, 2002. ,
Left ventricular noncompaction: a new form of heart failure, Heart Fail Clin, vol.6, issue.4, p.20869646, 2010. ,
Left ventricular noncompaction cardiomyopathy: updated review, Ther Adv Cardiovasc Dis, vol.7, issue.5, pp.260-73, 2013. ,
Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy. Circulation, vol.108, p.14623814, 2003. ,
Left ventricular solid body rotation in non-compaction cardiomyopathy: a potential new objective and quantitative functional diagnostic criterion?, Eur J Heart Fail, vol.10, issue.11, p.18815069, 2008. ,
Morphological varieties of the Purkinje fiber network in mammalian hearts, as revealed by light and electron microscopy, Arch Histol Cytol, vol.72, issue.3, p.20513977, 2009. ,
Transmural electrophysiological heterogeneity, the Twave and ventricular arrhythmias, Prog Biophys Mol Biol, vol.122, issue.3, p.27221779, 2016. ,
Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein, J Clin Invest, vol.108, issue.2, pp.189-201, 2001. ,
Excessive trabeculations in noncompaction do not have the embryonic identity, Int J Cardiol, vol.227, p.27838129, 2017. ,
Prognostic impact of left ventricular noncompaction in patients with Duchenne/Becker muscular dystrophy-Prospective multicenter cohort study, Int J Cardiol, p.23333368, 2013. ,
Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling, JCI Insight, vol.2, issue.6, p.88271, 2017. ,
Six1 is down-regulated in end-stage human dilated cardiomyopathy independently of Ezh2, ESC Heart Fail, vol.1, issue.2, p.5024036, 2014. ,
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus, BMC Dev Biol, p.31338, 2001. ,
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP, Nat Genet, vol.25, issue.2, pp.139-179, 2000. ,
Architectural and functional asymmetry of the His-Purkinje system of the murine heart, Cardiovasc Res, vol.63, issue.1, p.15194464, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-00311138
Investigation of connexin gene expression patterns by in situ hybridization techniques, Methods Mol Biol, vol.154, p.11218643, 2001. ,
Myocardial blood flow mapping in mice using high-resolution spin labeling magnetic resonance imaging: influence of ketamine/xylazine and isoflurane anesthesia, Magn Reson Med, vol.53, issue.3, p.15723407, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-02119119
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository, Nucleic Acids Res, vol.30, issue.1, p.99122, 2002. ,