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Article Dans Une Revue Cellular and Molecular Life Sciences Année : 2017

Control of DNA integrity in skeletal muscle under physiological and pathological conditions

Résumé

Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health.
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Dates et versions

hal-01826913 , version 1 (12-12-2019)

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Yara Bou Saada, Vlada Zakharova, Boris Chernyak, Carla Dib, Gilles Carnac, et al.. Control of DNA integrity in skeletal muscle under physiological and pathological conditions. Cellular and Molecular Life Sciences, 2017, 74 (19), pp.3439 - 3449. ⟨10.1007/s00018-017-2530-0⟩. ⟨hal-01826913⟩
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