Control of DNA integrity in skeletal muscle under physiological and pathological conditions

Abstract : Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health.
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https://hal.umontpellier.fr/hal-01826913
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Soumis le : jeudi 12 décembre 2019 - 16:21:36
Dernière modification le : lundi 10 février 2020 - 18:14:09

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2017 Bou Saada et al., Control...
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Yara Bou Saada, Vlada Zakharova, Boris Chernyak, Carla Dib, Gilles Carnac, et al.. Control of DNA integrity in skeletal muscle under physiological and pathological conditions. Cellular and Molecular Life Sciences, Springer Verlag, 2017, 74 (19), pp.3439 - 3449. ⟨10.1007/s00018-017-2530-0⟩. ⟨hal-01826913⟩

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