G. Der-johannes, . Mainz, and G. Mainz, 100 University of Medicine and Pharmacy Victor Babes, Royal Brompton Hospital NHS, issue.101

C. Medico-docente-la-trinidad-allergologia, S. Medicina-internahebron, . Barcelona, and . Spain, 121 ICVS/3B's?PT Government Associate Laboratory, Life and Health Sciences, Research Institute (ICVS), School of Health Sciences 123 EIP on AHA, European Innovation Partnership on Active and Healthy Ageing, Reference Site, Scottish Centre for Telehealth and Telecare, NHS 24, Glasgow, UK. 124 Department of Pediatric, Imperial College London, London, UK. 125 The Centre for Allergy Research, The Institute of Environmental Medicine 126 Department of Dermatology and Allergy 127 ZAUM?Center for Allergy and Environment 129 EUREGHA, European Regional and Local Health Association, Brussels, Belgium. 130 Allergology and Immunology Discipline 132 Peercode DV, Amsterdam, The Netherlands. 133 Respiratory Diseases Department, Rangueil?Larrey Hospital 139 Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, UK. 140 Guy's and St Thomas' NHS Trust, Kings College London The Bambino Gesù Children's Research Hospital Holy See, 103 National Heart and Lung Institute Campo dos Martires da Patria, Lisbon, Portugal. 107 Serviço de Imunoalergologia 118 Pulmonolory Research Institute FMBA, Moscow, Russia. 119 GARD Executive Committee, Moscow, Russia. 120 Medicine Department. 146 Global Allergy and Asthma Platform GAAPP, Altgasse 8?10, 1130 Vienna, Austria. 147 Division of Allergy 151 National Center for Disease Control and Public Health of Georgia Center of Tuberculosis and Lung Diseases, Latvian Association of Allergists. 158 National eHealth Centre Vienna Challenge Chamber, pp.156-157

. Bousquet, ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle, Clinical and Translational Allergy, vol.6, issue.4, p.47, 2016.
DOI : 10.1016/j.eurger.2015.03.008
URL : https://hal.archives-ouvertes.fr/hal-01822793

F. Bicêtre, . Anyang, . Gyeonggi?do, . South-korea-germantown, and U. Tn, The Netherlands. 186 Depart? ment of Immunology 187 Children's Hospital Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University 195 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. 196 Department of Pulmonary Medicine, CHU Sart?Tilman, Liege, Belgium. 197 Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysi? ology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. 198 The Queen's Medical Research Institute 201 Department of Pulmonary Medicine, Rashid Hospital 203 Department of Respiratory Medicine 204 Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine 206 Depart? ment of Medicine (RCSI), Bon Secours Hospital, Glasnevin, Dublin, Ireland. 207 Kronikgune, Basque Region, Spain. 208 Laboratory of Behavioral Immunol? ogy Research, Division of Clinical Immunology and Allergy, The University of Mississippi Medical Center 209 Tobacco Control Research Centre, Iranian Anti Tobacco Association 210 Department of Paediatrics, Maputo Central Hospital, Maputo, Mozambique. 211 Allergy and Asthma Medical Group and Research Center 217 Serbian Association for Asthma and COPD, Belgrade, Serbia. 218 Caisse d'assurance retraite et de la santé au travail du Languedoc?Roussillon (CARSAT?LR) 220 Department of Public Health and Health Products 223 Food Allergy Referral Centre Veneto Region 224 Scientific Centre of Chil? dren's Health Under the Russian Academy of Medical Sciences 236 Department of Immunology and Allergology, Faculty of Medicine and Faculty Hospital in Pilsen 245 Children's Hospital Srebrnjak The Netherlands, 169 Libra Foundation, Buenos Aires, Argentina. 170 Airway Disease Infection Section, National Heart and Lung Institute. 171 MRC & Asthma UK Centre in Allergic Mechanisms of Asthma UK. 199 Service de Pneumo?allergologie, Hôpital Saint?Joseph Service de Pneumologie, UMR INSERM, UMR1087 and CNR 6291, l'institut du Thorax. 222 Institute of Medical Statistics. 226 Hospital of the Hospitaller Brothers in Buda 230 National Hospital Organization. 242 Conseil Général de l'Economie, Ministère de l'Economie, de l'Industrie et du Numérique 247 Karl Landsteiner Institute for Clinical and Experimental Pneumology, Hietzing Hospital, Vienna, Austria. 248 Clinic of Allergy and Asthma 257 Polibien? estar Research Institute UK. 272 Royal Belfast Hospital for Sick Children Sociedad Paraguaya de Alergia Asma e Inmunolog?a Julius Center of Health Sciences and Primary Care Kyrgyzstan National Centre of Cardiology and Internal Medicine Pulmonary Division, Heart Institute (InCor) Hospital da Clinicas da Page, pp.274-275, 1209.

S. M. Arcispedale, /. Nuova, R. Irccs, and . Hospital, The Netherlands. 282 Pneumology and Allergy Department, Hospital Clínic, Clinical and Experi? mental Respiratory Immunoallergy, IDIBAPS, Barcelona, Spain. 283 PELyon 284 HESPER 7425, Health Services and Performance Resarch, 290 Finnish Lung Association (FILHA) CNR Institute of Biomedicine and Molecular Immunology " A, pp.291-292

. Monroy, Chapel Hill, NC, USA. 299 IPCRG, Aberdeen, Scotland, UK. 300 Bradford Institute for Health Research UK. 301 Department of Research, Olmsted Medical Center 303 The Allergy and Asthma Institute References 1 Allergic rhinitis and its impact on asthma, 293 Sotiria Hospital. 305 Department of Paediatrics and Child Health, Red Cross Children's Hospital, 2001.

P. Shekelle, S. Woolf, M. Eccles, and J. Grimshaw, Clinical guidelines: Developing guidelines, BMJ, vol.318, issue.7183, pp.593-599, 1999.
DOI : 10.1136/bmj.318.7183.593

J. Bousquet, N. Khaltaev, A. Cruz, J. Denburg, W. Fokkens et al., Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in col? laboration with the World Health Organization

, Allergy, vol.63, pp.8-160, 2008.

J. Brozek, E. Akl, P. Alonso?coello, D. Lang, R. Jaeschke et al., Grading quality of evidence and strength of recommendations in clinical practice guidelines, Allergy, vol.4, issue.5, pp.669-77, 2009.
DOI : 10.1136/bmj.315.7109.629

J. Brozek, C. Baena?cagnani, S. Bonini, G. Canonica, G. Rasi et al., Methodology for development of the Allergic Rhinitis and its Impact on Asthma Guideline 2008 update, Allergy, vol.4, issue.5 Suppl., pp.38-46, 2008.
DOI : 10.1136/bmj.318.7183.593

J. Brozek, J. Bousquet, C. Baena?cagnani, S. Bonini, G. Canonica et al., Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision, Journal of Allergy and Clinical Immunology, vol.126, issue.3, pp.466-76, 2010.
DOI : 10.1016/j.jaci.2010.06.047

A. Padjas, R. Kehar, S. Aleem, F. Mejza, J. Bousquet et al., Methodological rigor and reporting of clinical practice guidelines in patients with allergic rhinitis: QuGAR study, Journal of Allergy and Clinical Immunology, vol.133, issue.3, pp.777-783, 2014.
DOI : 10.1016/j.jaci.2013.08.029

J. Bousquet, H. Schunemann, B. Samolinski, P. Demoly, C. Baena?cagnani et al., Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs, Journal of Allergy and Clinical Immunology, vol.130, issue.5, pp.1049-62, 2012.
DOI : 10.1016/j.jaci.2012.07.053

J. Bousquet, H. Schunemann, J. Fonseca, B. Samolinski, C. Bachert et al., MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation, Allergy, vol.5, issue.Suppl 72, pp.1372-92, 2015.
DOI : 10.1016/j.eurger.2014.07.011
URL : https://hal.archives-ouvertes.fr/hal-01978121

J. Bousquet, J. Michel, T. Standberg, G. Crooks, I. Iakovidis et al., The European Innovation Partnership on Active and Healthy Ageing: The European geriatric medicine introduces the EIP on AHA column, European Geriatric Medicine, vol.5, issue.6, pp.361-363, 2014.
DOI : 10.1016/j.eurger.2014.09.010

J. Bousquet, A. Addis, I. Adcock, I. Agache, A. Agusti et al., Integrated care pathways for airway diseases (AIRWAYS-ICPs), European Respiratory Journal, vol.44, issue.2, pp.304-327, 2014.
DOI : 10.1183/09031936.00014614

J. Bousquet, C. Barbara, E. Bateman, E. Bel, M. Bewick et al., AIRWAYS-ICPs (European Innovation Partnership on Active and Healthy Ageing) from concept to implementation, European Respiratory Journal, vol.47, issue.4, pp.1028-1061, 2016.
DOI : 10.1183/13993003.01856-2015
URL : https://hal.archives-ouvertes.fr/hal-01872376

J. Bousquet, J. Anto, K. Berkouk, P. Gergen, J. Antunes et al., Developmental determinants in non-communicable chronic diseases and ageing, Thorax, vol.133, issue.6, pp.595-602, 2015.
DOI : 10.1016/j.jaci.2014.01.018
URL : https://hal.archives-ouvertes.fr/hal-01263281

J. Bousquet, J. Farrell, G. Crooks, P. Hellings, E. Bel et al., Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5), Clinical and Translational Allergy, vol.2, issue.10, pp.29-39, 2016.
DOI : 10.1016/S2213-2600(14)70188-2
URL : https://hal.archives-ouvertes.fr/hal-01821925

J. Bousquet, R. Dahl, and N. Khaltaev, Global Alliance against Chronic Respiratory Diseases, Allergy, vol.8, issue.Suppl. 1, pp.216-239, 2007.
DOI : 10.1136/bmj.314.7084.860
URL : https://hal.archives-ouvertes.fr/inserm-01401204

T. Glossary, One?VA technical reference model v14.10. US Department of Veteran Affairs, 2014.

, National Institutes of Health. Clinical practice guidelines, National Center for Complementary and Alternative Medicine (NCCAM)

K. Zander, Historical Development of Outcomes-Based Care Delivery, Critical Care Nursing Clinics of North America, vol.10, issue.1, pp.1-11, 1998.
DOI : 10.1016/S0899-5885(18)30222-3

H. Campbell, R. Hotchkiss, N. Bradshaw, and M. Porteous, Integrated care pathways, BMJ, vol.316, issue.7125, pp.133-140, 1998.
DOI : 10.1136/bmj.316.7125.133

S. Overill, A Practical Guide to Care Pathways, Journal of Integrated Care, vol.316, issue.3, pp.93-101, 1998.
DOI : 10.1136/bmj.316.7125.133

, Integrated Care Pathways users in Scotland (ICPUS) A workbook for people starting to develop integrated care pathways

, How to produce and evaluate an integrated care pathway (ICP): information for staff. Great Ormond Street Hospital for Children

, ARIA in the pharmacy: management of allergic rhinitis symptoms in the pharmacy. Allergic rhinitis and its impact on asthma, Allergy, vol.59, issue.4, pp.373-87, 2004.

J. Bousquet, F. Neukirch, P. Bousquet, P. Gehano, J. Klossek et al., Severity and impairment of allergic rhinitis in patients consulting in primary care, Journal of Allergy and Clinical Immunology, vol.117, issue.1, pp.158-62, 2006.
DOI : 10.1016/j.jaci.2005.09.047

J. Bousquet, I. Annesi?maesano, F. Carat, D. Leger, M. Rugina et al., Characteristics of intermittent and persistent allergic rhinitis: DREAMS study group, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.96, issue.1, pp.728-760, 2005.
DOI : 10.1034/j.1398-9995.2001.00991.x

P. Bousquet, P. Devillier, A. Tadmouri, K. Mesbah, P. Demoly et al., Clinical Relevance of Cluster Analysis in Phenotyping Allergic Rhinitis in a Real-Life Study, International Archives of Allergy and Immunology, vol.166, issue.3, pp.231-271, 2015.
DOI : 10.1159/000381339
URL : https://hal.archives-ouvertes.fr/hal-02005980

A. Del-cuvillo, J. Montoro, J. Bartra, A. Valero, M. Ferrer et al., Validation of ARIA duration and severity classifications in Spanish allergic rhinitis patients - The ADRIAL cohort study, Rhinology Journal, vol.48, issue.2, pp.201-206, 2010.
DOI : 10.4193/Rhin09.099

I. Jauregui, I. Davila, J. Sastre, J. Bartra, A. Del-cuvillo et al., Validation of ARIA (Allergic Rhinitis and its Impact on Asthma) classification in a pediatric population: The PEDRIAL study, Pediatric Allergy and Immunology, vol.21, issue.Suppl. 1, pp.388-92, 2011.
DOI : 10.1111/j.1399-3038.2009.00933.x

A. Cruz, T. Popov, R. Pawankar, I. Annesi?maesano, W. Fokkens et al., LEN, Allergy, vol.15, issue.2, pp.1-41, 2007.
DOI : 10.1111/j.1398-9995.2004.00550.x
URL : https://hal.archives-ouvertes.fr/hal-00595859

G. Canonica, J. Bousquet, J. Mullol, G. Scadding, and J. Virchow, A survey of the burden of allergic rhinitis in Europe, Allergy, vol.46, issue.s85, pp.17-25, 2007.
DOI : 10.1016/S0091-6749(00)90177-5

P. Bousquet, P. Demoly, P. Devillier, K. Mesbah, and J. Bousquet, Impact of Allergic Rhinitis Symptoms on Quality of Life in Primary Care, International Archives of Allergy and Immunology, vol.150, issue.4, pp.393-400, 2013.
DOI : 10.1159/000210383

D. Price, G. Scadding, D. Ryan, C. Bachert, G. Canonica et al., The hidden burden of adult allergic rhinitis: UK healthcare resource utilisation survey, Clinical and Translational Allergy, vol.67, issue.Suppl 85, p.39, 2015.
DOI : 10.1111/all.12686
URL : https://hal.archives-ouvertes.fr/hal-01899416

, EPR?3): guidelines for the diagnosis and man? agement of asthma?summary report 2007, Expert Panel Report J Allergy Clin Immunol, vol.3120, issue.5, pp.94-138, 2007.

O. Byrne, P. Reddel, H. Eriksson, G. Ostlund, O. Peterson et al., Measuring asthma control: a comparison of three classification systems, European Respiratory Journal, vol.36, issue.2, pp.269-76, 2010.
DOI : 10.1183/09031936.00124009

H. Reddel, E. Bateman, A. Becker, L. Boulet, A. Cruz et al., A summary of the new GINA strategy: a roadmap to asthma control, European Respiratory Journal, vol.46, issue.3, pp.622-661, 2015.
DOI : 10.1183/13993003.00853-2015

J. Bousquet, C. Bourquin, P. Augé, P. Domy, J. Bringer et al., MACVIA-LR, Reference site of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) in Languedoc Roussillon, European Geriatric Medicine, vol.5, issue.6, pp.406-421, 2014.
DOI : 10.1016/j.eurger.2014.07.013
URL : https://hal.archives-ouvertes.fr/hal-01743369

R. Bourret, J. Bousquet, J. Mercier, T. Camuzat, A. Bedbrook et al., MASK rhinitis, a single tool for integrated care pathways in allergic rhinitis, World Hosp Health Serv, vol.51, issue.3, pp.36-45, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01767848

J. Bousquet, C. Bachert, G. Canonica, J. Mullol, P. Van-cauwenberge et al., LEN study, Allergy, vol.22, issue.10, pp.1516-1539, 2009.
DOI : 10.1164/ajrccm.162.4.9912033
URL : https://hal.archives-ouvertes.fr/hal-01745368

J. Bousquet, C. Bachert, G. Canonica, J. Mullol, P. Van-cauwenberge et al., Efficacy of Desloratadine in Persistent Allergic Rhinitis ??? A GA<sup>2</sup>LEN Study, International Archives of Allergy and Immunology, vol.153, issue.4, pp.395-402, 2010.
DOI : 10.1159/000316351

M. Morais?almeida, N. Santos, A. Pereira, M. Branco?ferreira, C. Nunes et al., Prevalence and classification of rhinitis in preschool children in Portugal: a nationwide study, Allergy, vol.100, issue.6 Pt 1, pp.1278-88, 2013.
DOI : 10.1111/j.1651-2227.2011.02240.x

M. Morais?almeida, H. Pite, A. Pereira, A. Todo?bom, C. Nunes et al., Prevalence and classification of rhinitis in the elderly: a nationwide survey in Portugal, Allergy, vol.1, issue.Suppl 86, pp.1150-1157, 2013.
DOI : 10.1016/S0140-6736(08)61446-4

L. Klimek, C. Bachert, R. Mosges, U. Munzel, D. Price et al., Effectiveness of MP29-02 for the treatment of allergic rhinitis in real-life: Results from a noninterventional study, Allergy and Asthma Proceedings, vol.36, issue.1, pp.40-47, 2015.
DOI : 10.2500/aap.2015.36.3823

K. Ohta, P. Bousquet, H. Aizawa, K. Akiyama, M. Adachi et al., Prevalence and impact of rhinitis in asthma. SACRA, a cross-sectional nation-wide study in Japan, Allergy, vol.32, issue.1 Suppl., pp.1287-95, 2011.
DOI : 10.1183/09031936.00053108

D. Larenas?linnemann, H. Dinger, K. Shah?hosseini, A. Michels, and R. Mosges, Over Diagnosis of Persistent Allergic Rhinitis in Perennial Allergic Rhinitis Patients: A Nationwide Study in Mexico, American Journal of Rhinology & Allergy, vol.50, issue.1, pp.495-501, 2013.
DOI : 10.1185/03007995.2012.724393

J. Shao, Y. Cui, Y. Zheng, H. Peng, Z. Zheng et al., Efficacy and Safety of Sublingual Immunotherapy in Children Aged 3???13 Years with Allergic Rhinitis, American Journal of Rhinology & Allergy, vol.11, issue.2, pp.131-140, 2014.
DOI : 10.1016/j.rmed.2005.11.016

H. Wei, Y. Zhang, L. Shi, J. Zhang, Y. Xia et al., Higher Dosage of HIFU Treatment May Lead to Higher and Longer Efficacy for Moderate to Severe Perennial Allergic Rhinitis, International Journal of Medical Sciences, vol.10, issue.13, pp.1914-1934, 2013.
DOI : 10.7150/ijms.7117
URL : http://www.medsci.org/v10p1914.pdf

E. Tatar, U. Surenoglu, G. Saylam, E. Isik, A. Ozdek et al., Is there any Correlation between the Results of Skin-Prick Test and the Severity of Symptoms in Allergic Rhinitis?, American Journal of Rhinology & Allergy, vol.24, issue.1, pp.37-46, 2012.
DOI : 10.1016/j.jaci.2009.02.018

P. Bousquet, L. Bousquet?rouanet, C. Minh, H. Urbinelli, R. Allaert et al., ARIA (Allergic Rhinitis and Its Impact on Asthma) Classification of Allergic Rhinitis Severity in Clinical Practice in France, International Archives of Allergy and Immunology, vol.55, issue.3, pp.163-172, 2007.
DOI : 10.1111/j.1365-2222.1991.tb00807.x

S. Rouve, A. Didier, P. Demoly, R. Jankowsky, J. Klossek et al., Numeric score and visual analog scale in assessing seasonal allergic rhinitis severity, Rhinology Journal, vol.48, issue.3, pp.285-91, 2010.
DOI : 10.4193/Rhin09.208
URL : https://hal.archives-ouvertes.fr/hal-00598337

I. Baiardini, F. Braido, S. Brandi, F. Tarantini, S. Bonini et al., LEN review, Allergy, vol.336, issue.Suppl 5, pp.1015-1045, 2008.
DOI : 10.1164/ajrccm.162.4.9912033

H. Yamamoto, T. Yamada, M. Sakashita, S. Kubo, D. Susuki et al., Efficacy of prophylactic treatment with montelukast and montelukast plus add-on loratadine for seasonal allergic rhinitis, Allergy and Asthma Proceedings, vol.33, issue.2, pp.17-22, 2012.
DOI : 10.2500/aap.2012.33.3514

P. Bousquet, C. Bachert, G. Canonica, T. Casale, J. Mullol et al., Uncontrolled allergic rhinitis during treatment and its impact on quality of life: A??cluster randomized trial, Journal of Allergy and Clinical Immunology, vol.126, issue.3, pp.666-668, 2010.
DOI : 10.1016/j.jaci.2010.06.034

P. Demoly, P. Bousquet, K. Mesbah, J. Bousquet, and P. Devillier, Visual analogue scale in patients treated for allergic rhinitis: an observational prospective study in primary care, Clinical & Experimental Allergy, vol.5, issue.8, pp.881-889, 2013.
DOI : 10.1007/BF00435976

P. Bousquet, C. Combescure, J. Klossek, J. Daures, and J. Bousquet, Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis, Journal of Allergy and Clinical Immunology, vol.123, issue.6, pp.1349-54, 2009.
DOI : 10.1016/j.jaci.2009.02.033

E. Vuurman, L. Vuurman, I. Lutgens, and B. Kremer, Allergic rhinitis is a risk factor for traffic safety, Allergy, vol.16, issue.Suppl 1, pp.906-918, 2014.
DOI : 10.1177/026988110201600104

J. Hellgren, A. Cervin, S. Nordling, A. Bergman, and L. Cardell, Allergic rhinitis and the common cold - high cost to society, Allergy, vol.9, issue.Suppl. 86, pp.776-83, 2010.
DOI : 10.1111/j.1398-9995.2009.02269.x

T. Zuberbier, J. Lotvall, S. Simoens, S. Subramanian, and M. Church, LEN review, Allergy, vol.118, issue.10, pp.1275-1284, 2014.
DOI : 10.1016/j.jaci.2006.02.031

C. Lamb, P. Ratner, C. Johnson, A. Ambegaonkar, A. Joshi et al., Economic impact of workplace productivity losses due to allergic rhinitis compared with select medical conditions in the United States from an employer perspective, Current Medical Research and Opinion, vol.22, issue.6, pp.1203-1213, 2006.
DOI : 10.1185/030079906X112552

S. Walker, S. Khan?wasti, M. Fletcher, P. Cullinan, J. Harris et al., Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: Case-control study, Journal of Allergy and Clinical Immunology, vol.120, issue.2, pp.381-388, 2007.
DOI : 10.1016/j.jaci.2007.03.034

H. Nolte, S. Nepper?christensen, and V. Backer, Unawareness and undertreatment of asthma and allergic rhinitis in a general population, Respiratory Medicine, vol.100, issue.2, pp.354-62, 2006.
DOI : 10.1016/j.rmed.2005.05.012

J. Bousquet, H. Schunemann, P. Hellings, S. Arnavielhe, C. Bachert et al., MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis, Journal of Allergy and Clinical Immunology, vol.138, issue.2, pp.367-374, 2016.
DOI : 10.1016/j.jaci.2016.03.025
URL : https://doi.org/10.1016/j.jaci.2016.03.025

H. Konig, S. Bernert, M. Angermeyer, H. Matschinger, M. Martinez et al., Comparison of Population Health Status in Six European Countries, Medical Care, vol.47, issue.2, pp.255-61, 2009.
DOI : 10.1097/MLR.0b013e318184759e

A. Smith, A. Pitt, A. Rodruiguez, J. Alio, N. Marti et al., The Economic and Quality of Life Impact of Seasonal Allergic Conjunctivitis in a Spanish Setting, Ophthalmic Epidemiology, vol.91, issue.5, pp.233-275, 2005.
DOI : 10.1378/chest.91.6_Supplement.65S

. Bousquet, 6:47 ? We accept pre-submission inquiries ? Our selector tool helps you to find the most relevant journal ? We provide round the clock customer support ? Convenient online submission ? Thorough peer review ? Inclusion in PubMed and all major indexing services ? Maximum visibility for your research Submit your manuscript at www.biomedcentral, com/submit Submit your next manuscript to BioMed Central and we will help you at every step, 2016.

P. Blanc, L. Trupin, M. Eisner, G. Earnest, P. Katz et al., The work impact of asthma and rhinitis, Journal of Clinical Epidemiology, vol.54, issue.6, pp.610-618, 2001.
DOI : 10.1016/S0895-4356(00)00349-8

J. Bousquet, T. Bodez, P. Gehano, J. Klossek, F. Liard et al., Implementation of Guidelines for Allergic Rhinitis in Specialist Practices, International Archives of Allergy and Immunology, vol.150, issue.1, pp.75-82, 2009.
DOI : 10.1159/000210383

K. Ohta, J. Bousquet, P. Akiyama, K. Adachi, M. Ichinose et al., Visual Analog Scale as a Predictor of GINA-Defined Asthma Control. The SACRA Study in Japan, Journal of Asthma, vol.32, issue.86, pp.514-535, 2013.
DOI : 10.1183/09031936.00155307

M. Hojo, K. Ohta, M. Iikura, T. Mizutani, J. Hirashima et al., Clinical usefulness of a guideline-based screening tool for the diagnosis of allergic rhinitis in asthmatics: The Self Assessment of Allergic Rhinitis and Asthma questionnaire, Respirology, vol.27, issue.6, pp.1016-1037, 2013.
DOI : 10.1185/03007995.2011.630722

P. Sullivan, K. Smith, V. Ghushchyan, D. Globe, S. Lin et al., Asthma in USA: its impact on health-related quality of life, Journal of Asthma, vol.326, issue.8, pp.891-900, 2013.
DOI : 10.1056/NEJM199202203260801

S. Van-der-leeuw, T. Van-der-molen, P. Dekhuijzen, J. Fonseca, F. Van-gemert et al., The minimal clinically important difference of the control of allergic rhinitis and asthma test (CARAT): cross-cultural validation and relation with pollen counts, npj Primary Care Respiratory Medicine, vol.29, issue.1, p.14107, 2015.
DOI : 10.1046/j.1365-2222.1999.00434.x

G. Ciprandi, I. Schiavetti, V. Sorbello, and F. Ricciardolo, Perception of Asthma Symptoms as Assessed on the Visual Analog Scale in Subjects With Asthma: A Real-Life Study, Respiratory Care, vol.61, issue.1, pp.23-32, 2016.
DOI : 10.4187/respcare.04171

D. Belgrave, I. Buchan, C. Bishop, L. Lowe, A. Simpson et al., Trajectories of Lung Function during Childhood, American Journal of Respiratory and Critical Care Medicine, vol.9, issue.9, pp.1101-1110, 2014.
DOI : 10.1164/rccm.201110-1922OC
URL : http://europepmc.org/articles/pmc4098108?pdf=render

J. Bousquet, J. Anto, J. Sunyer, M. Nieuwenhuijsen, M. Vrijheid et al., Pooling Birth Cohorts in Allergy and Asthma: European Union-Funded Initiatives ?? A MeDALL, CHICOS, ENRIECO, and GA2LEN Joint Paper, International Archives of Allergy and Immunology, vol.170, issue.1, pp.1-10, 2013.
DOI : 10.1093/aje/kwp211

J. Anto, M. Pinart, M. Akdis, C. Auffray, C. Bachert et al., Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar, Journal of Allergy and Clinical Immunology, vol.129, issue.4, pp.943-954, 2012.
DOI : 10.1016/j.jaci.2012.01.047

J. Bousquet, J. Anto, C. Auffray, M. Akdis, A. Cambon?thomsen et al., MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine, Allergy, vol.126, issue.Suppl. 1, pp.596-604, 2011.
DOI : 10.1016/j.jaci.2010.07.019
URL : https://hal.archives-ouvertes.fr/hal-00595853

J. Bousquet, J. Anto, M. Akdis, C. Auffray, T. Keil et al., Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story, Allergy, vol.133, issue.5 Suppl, pp.1513-1538, 2016.
DOI : 10.1016/j.jaci.2013.10.030
URL : https://hal.archives-ouvertes.fr/hal-01872911

N. Ballardini, A. Bergstrom, C. Wahlgren, M. Van-hage, E. Hallner et al., IgE antibodies in relation to prevalence and multimorbidity of eczema, asthma, and rhinitis from birth to adolescence, Allergy, vol.113, issue.Suppl 15, pp.342-351, 2016.
DOI : 10.1016/j.jaci.2003.12.591

S. Gabet, J. Just, R. Couderc, J. Bousquet, N. Seta et al., Early polysensitization is associated with allergic multimorbidity in PARIS birth cohort infants, Pediatric Allergy and Immunology, vol.189, issue.8, pp.831-868, 2016.
DOI : 10.1177/003335490612100111
URL : https://hal.archives-ouvertes.fr/hal-01830040

E. Burte, J. Bousquet, R. Varraso, F. Gormand, J. Just et al., Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study, PLOS ONE, vol.27, issue.6, p.136191, 2015.
DOI : 10.1371/journal.pone.0136191.s002
URL : https://hal.archives-ouvertes.fr/hal-01231006

V. Siroux, C. Lupinek, Y. Resch, M. Curin, J. Just et al., Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study, Journal of Allergy and Clinical Immunology, vol.139, issue.2
DOI : 10.1016/j.jaci.2016.05.023
URL : https://hal.archives-ouvertes.fr/inserm-01815134

J. Just, C. Elegbede, A. Deschildre, J. Bousquet, D. Moneret?vautrin et al., Three peanut-allergic/sensitized phenotypes with gender difference, Clinical & Experimental Allergy, vol.108, issue.12, pp.1596-1604, 2016.
DOI : 10.1067/mai.2001.119028
URL : https://hal.archives-ouvertes.fr/hal-01377021

M. Bresciani, L. Paradis, D. Roches, A. Vernhet, H. Vachier et al., Rhinosinusitis in severe asthma, Journal of Allergy and Clinical Immunology, vol.107, issue.1, pp.73-80, 2001.
DOI : 10.1067/mai.2001.111593

A. Ten-brinke, D. Grootendorst, J. Schmidt, D. Bruine, F. Van-buchem et al., Chronic sinusitis in severe asthma is related to sputum eosinophilia, Journal of Allergy and Clinical Immunology, vol.109, issue.4, pp.621-627, 2002.
DOI : 10.1067/mai.2002.122458

A. Ten-brinke, P. Sterk, A. Masclee, P. Spinhoven, J. Schmidt et al., Risk factors of frequent exacerbations in difficult-to-treat asthma, European Respiratory Journal, vol.26, issue.5, pp.812-820, 2005.
DOI : 10.1183/09031936.05.00037905

N. Wilson, M. Bewick, and W. Dziworski, Maintaining health despite chronic illness in the elderly: A multi-disciplinary study visit to the north of England region, European Geriatric Medicine, vol.6, issue.4, pp.396-400, 2015.
DOI : 10.1016/j.eurger.2015.03.008