Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans. - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Prostaglandins and Other Lipid Mediators Année : 2013

Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans.

Claudio de Felice

Résumé

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

Domaines

Chimie organique
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Dates et versions

hal-00913158 , version 1 (03-06-2021)

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Jean-Marie Galano, Emilie Mas, Anne Barden, Trevor A Mori, Cinzia Signorini, et al.. Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans.. Prostaglandins and Other Lipid Mediators, 2013, 107, pp.95-102. ⟨10.1016/j.prostaglandins.2013.04.003⟩. ⟨hal-00913158⟩
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