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Subacute static magnetic field exposure in rat induces a pseudoanemia status with increase in MCT4 and Glut4 proteins in glycolytic muscle

Abstract : The purpose of this study was to investigate the effect of subacute exposure to static magnetic fields (SMF) on hematological and muscle biochemical parameters in rats. Male Wistar rats, daily exposed to SMF, were exposed to SMF (128 mT, 1 h/day) during 15 consecutive days. SMF-exposed rats showed a significant decrease in red blood cell (RBC) count, hemoglobin (Hb), and hematocrit (Ht) values compared to sham-exposed rats (p < 0.05). Concomitant decreases of plasma iron level against increase in transferrin amount were also observed after SMF exposure (p < 0.0.05). In postprandial condition, SMF-exposed rats presented higher plasma lactate (p < 0.01). Additionally, SMF exposure increased monocarboxylate transporters (MCT4) and glucose transporter 4 (Glut4)'s contents only in glycolytic muscle (p < 0.05). SMF exposure induced alteration of hematological parameters; importantly, we noticed a pseudoanemia status, which seems to affect tissue oxygen delivery. Additionally, SMF exposure seems to favor the extrusion of lactate from the cell to the blood compartment. Given that, these arguments advocate for an adaptive response to a hypoxia status following SMF exposure.
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https://hal.umontpellier.fr/hal-01817677
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Soumis le : mercredi 4 décembre 2019 - 15:47:00
Dernière modification le : vendredi 15 mai 2020 - 12:22:08
Document(s) archivé(s) le : jeudi 5 mars 2020 - 19:23:39

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Miryam Elferchichi, Jacques Mercier, Mohamed Ammari, Hatem Belguith, Hafedh Abdelmelek, et al.. Subacute static magnetic field exposure in rat induces a pseudoanemia status with increase in MCT4 and Glut4 proteins in glycolytic muscle. Environmental Science and Pollution Research, Springer Verlag, 2016, 23 (2), pp.1265-1273. ⟨10.1007/s11356-015-5336-3⟩. ⟨hal-01817677⟩

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