Effect of tamoxifen and fulvestrant long-term treatments on ROS production and (pro/anti)-oxidant enzymes mRNA levels in a MCF-7-derived breast cancer cell line

Abstract : Reactive oxygen species (ROS) are key players in the apoptotic effects induced by short-term tamoxifen treatment of breast cancer cells, but also in acquired resistance following long-term treatment. Whereas the use of the selective estrogen receptor down-regulator fulvestrant is promising, especially in patients who develop tamoxifen resistance, only few studies addressed its implication in the modulation of cellular redox status.
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Eric Badia, Marion Morena, Céline Lauret, Abdelhay Boulahtouf, Nathalie Boulle, et al.. Effect of tamoxifen and fulvestrant long-term treatments on ROS production and (pro/anti)-oxidant enzymes mRNA levels in a MCF-7-derived breast cancer cell line. Breast Cancer, Springer Verlag, 2016, 23 (5), pp.692 - 700. ⟨10.1007/s12282-015-0626-7⟩. ⟨hal-01802789⟩

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