The high frequency relationship: implications for torsadogenic hERG blockers

Abstract : Ventricular arrhythmias induced by human ether-a-go-go related gene (hERG; Kv 11.1 channel) blockers are a consequence of alterations in ventricular repolarisation in association with high-frequency (HF) oscillations, which act as a primary trigger; the autonomic nervous system plays a modulatory role. In the present study, we investigated the role of β1 -adrenoceptors in the HF relationship between magnitude of heart rate and QT interval changes within discrete 10 s intervals (sorted into 5 bpm heart rate increments) and its implications for torsadogenic hERG blockers.
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British Journal of Pharmacology, Wiley, 2016, 173 (3), pp.601 - 612. 〈10.1111/bph.13391〉
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Contributeur : Dominique Mornet <>
Soumis le : mercredi 2 mai 2018 - 10:50:24
Dernière modification le : dimanche 24 juin 2018 - 13:24:02

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P Champeroux, Jean-Yves Le Guennec, S Jude, C Laigot, A Maurin, et al.. The high frequency relationship: implications for torsadogenic hERG blockers. British Journal of Pharmacology, Wiley, 2016, 173 (3), pp.601 - 612. 〈10.1111/bph.13391〉. 〈hal-01782907〉

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