Relaxin and atrial natriuretic peptide pathways participate in the anti-fibrotic effect of a melon concentrate in spontaneously hypertensive rats.

Abstract : In spontaneously hypertensive rats (SHR), a model of human essential hypertension, oxidative stress is involved in the development of cardiac hypertrophy and fibrosis associated with hypertension. Dietary supplementation with agents exhibiting antioxidant properties could have a beneficial effect in remodeling of the heart. We previously demonstrated a potent anti-hypertrophic effect of a specific melon (Cucumis melo L.) concentrate with antioxidant properties in spontaneously hypertensive rats. Relaxin and atrial natriuretic peptide (ANP) were reported to reduce collagen deposition and fibrosis progression in various experimental models.
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https://hal.umontpellier.fr/hal-01782857
Contributeur : Dominique Mornet <>
Soumis le : mercredi 2 mai 2018 - 10:42:29
Dernière modification le : jeudi 25 juillet 2019 - 16:44:08

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  • HAL Id : hal-01782857, version 1
  • PUBMED : 27079780

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Julie Carillon, Audrey Gauthier, Sandy Barial, Michel Tournier, Nathalie Gayrard, et al.. Relaxin and atrial natriuretic peptide pathways participate in the anti-fibrotic effect of a melon concentrate in spontaneously hypertensive rats.. Food and Nutrition Research, Swedish Nutrition Foundation, 2018, pp.30985. ⟨hal-01782857⟩

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