Relationship between Autophagy and Ventilator-induced Diaphragmatic Dysfunction

Abstract : Mechanical ventilation (MV) is associated with atrophy and weakness of the diaphragm muscle, a condition termed ventilator-induced diaphragmatic dysfunction (VIDD). Autophagy is a lysosomally mediated proteolytic process that can be activated by oxidative stress, which has the potential to either mitigate or exacerbate VIDD. The primary goals of this study were to (1) determine the effects of MV on autophagy in the diaphragm and (2) evaluate the impact of antioxidant therapy on autophagy induction and MV-induced diaphragmatic weakness.
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Soumis le : lundi 9 avril 2018 - 16:07:00
Dernière modification le : lundi 1 avril 2019 - 17:15:17




Ilan Azuelos, Boris Jung, Martin Picard, Feng Li, Tong Li, et al.. Relationship between Autophagy and Ventilator-induced Diaphragmatic Dysfunction. Anesthesiology, Lippincott, Williams & Wilkins, 2015, 122 (6), pp.1349 - 1361. ⟨10.1097/ALN.0000000000000656⟩. ⟨hal-01762097⟩



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