U. Cnrs and . De-montpellier, Inserm U1046, physiologie & médecine expérimentale, coeur et muscles, vol.34000

A. Gard, CHRU de Montpellier, département de neuropédiatrie, centre de référence Grand-Sud des maladies neuro-musculaires, Association asthme et allergie, 92100, vol.30000

L. Valériane, Association ADAGES, Les Passerelles d'ô, vol.34000, p.30000

, Université Montpellier 2, laboratoire de recherche système d'information -Montpellier Management recherche, p.34000

. Lbn-ea-4203, CHRU et Inserm U 1058, vol.34000

, UMR S 710, université de Montpellier, EPHE, section des sciences de la vie et de la terre, vol.75000

J. Bousquet and . De-montpellier, 34295 Montpellier cedex 5, France. jean.bousquet@orange.fr Déclaration d'intérêts : Jean Bousquet a reçu des honoraires de : Scientific and advisory boards -Almirall

C. Astrazeneca, . Gsk, . Meda, . Menarini, . Merck et al., Lectures during meetings-Almirall

. Références,

B. Rechel, E. Grundy, and J. M. Robine, Ageing in the European Union, Lancet, vol.381, pp.1312-1334, 2013.

J. E. Morley, B. Vellas, and G. A. Van-kan, Frailty consensus: a call to action, JAMA, vol.14, pp.392-399, 2013.

C. Jagger, C. Gillies, and F. Moscone, Inequalities in healthy life years in the 25 countries of the European Union in 2005: a cross-national meta-regression analysis, Lancet, vol.372, pp.2124-2155, 2008.

J. Bousquet, J. M. Anto, and P. J. Sterk, Systems medicine and integrated care to combat chronic noncommunicable diseases, Genome Med, vol.3, p.43, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01358549

J. Bousquet, Non-communicable chronic diseases, a global public health priority recognized by the United Nations

, Presse Med, vol.40, pp.787-796, 2011.

K. Barnett, S. W. Mercer, M. Norbury, G. Watt, S. Wyke et al., Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study, Lancet, vol.380, pp.37-43, 2012.

J. Bousquet, J. Hajjam, and F. Piette,

, Presse Med, vol.42, pp.1558-61, 2013.

J. Bousquet, C. Bourquin, and P. Augé, MACVIA-LR reference site of the European innovation partnership on active and healthy ageing, Eur Geriatr Med, vol.5, pp.406-421, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01743369

J. M. Robine, E. Cambois, W. Nusselder, B. Jeune, H. V. Oyen et al., The joint action on healthy life years (JA: EHLEIS), Arch Public Health, vol.71, issue.2, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00801389

J. Croswell and Y. R. Shin, Prevention of falls in community-dwelling older adults: recommendation statement, Am Fam Physician, vol.86, pp.1135-1141, 2012.

H. Blain, F. Abecassis, and P. Adnet, Living Lab Falls-MACVIA-LR: the falls prevention initiative of the European innovation partnership on active and healthy ageing (EIP on AHA, Eur Geriatr Med, vol.5, pp.416-441, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02097629

A. Clegg, J. Young, S. Iliffe, M. O. Rikkert, and K. Rockwood, Frailty in elderly people, Lancet, vol.381, pp.752-62, 2013.

, Action plan for the global strategy for the prevention and control of non communicable diseases. Prevent and control cardiovascular diseases, cancers, chronic respiratory diseases, diabetes, 2013.

, European Union Health Policy Forum. Answer to DG SANCO consultation on chronic diseases

J. Bousquet, C. Jorgensen, and M. Dauzat, System medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies, Curr Pharm Des, vol.20, pp.5928-5972, 2014.

R. Bourret and J. Bousquet, An integrated approach to telemonitoring noncommunicable diseases: best practice from the European innovation partnership on active and healthy ageing, World Hosp Health Serv, vol.49, pp.25-33, 2013.

P. Claret, B. Bobbia, P. Richard, F. Poher, and J. De-la-coussaye,

, Ann Fr Med Urgence, vol.4, pp.96-1015, 2014.

G. P. Redrow, C. M. Thompson, and R. Wang, Treatment strategies for diabetic patients suffering from erectile dysfunction: an update, Expert Opin Pharmacother, vol.15, pp.1827-1863, 2014.

G. Jackson, N. Boon, and I. Eardley, Erectile dysfunction and coronary artery disease prediction: evidence-based guidance and consensus, Int J Clin Pract, vol.64, pp.848-57, 2010.

G. Corona, C. B. Giorda, D. Cucinotta, P. Guida, and N. E. Group-s-ds, The SUBITO-DE study: sexual dysfunction in newly diagnosed type 2 diabetes male patients, J Endocrinol Invest, vol.36, pp.864-872, 2013.

P. Costa, G. Grandmottet, H. D. Mai, and S. Droupy, Impact of a first treatment with phosphodiesterase inhibitors on men and partners' quality of sexual life: results of a prospective study in primary care, J Sex Med, vol.10, pp.1850-60, 2013.

J. Bousquet, A. Addis, and I. Agache, Integrated care pathways for airway diseases (AIRWAYS ICPs), Eur Respir J, vol.44, pp.304-327, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02565409

S. J. Carson and M. Edwards, Barriers to providing dental care for older people, Evid Based Dent, vol.15, pp.14-19, 2014.

C. Hezode, H. Fontaine, and C. Dorival, Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC), J Hepatol, vol.59, pp.434-475, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01708037

S. Bota, I. Sporea, and R. Sirli, Severe adverse events during antiviral therapy in hepatitis C virus cirrhotic patients: a systematic review, World J Hepatol, vol.5, pp.120-126, 2013.

F. I. Lieveld, L. G. Van-vlerken, P. D. Siersema, and K. J. Van-erpecum, Patient adherence to antiviral treatment for chronic hepatitis B and C: a systematic review, Ann Hepatol, vol.12, pp.380-91, 2013.

D. Larrey, A. Salse, and D. Ribard, Education by a nurse increases response of patients with chronic hepatitis C to therapy with peginterferon-alpha2a and ribavirin, Clin Gastroenterol Hepatol, vol.9, pp.781-786, 2011.

D. Kuh, R. Cooper, R. Hardy, M. Richards, and Y. Ben-shlomo, A life course approach to healthy ageing, 2014.

N. J. Simmonds, Ageing in cystic fibrosis and long-term survival, Paediatr Respir Rev, vol.14, pp.6-9, 2013.

A. Mooventhan and L. Nivethitha, Scientific evidence-based effects of hydrotherapy on various systems of the body, North Am J Med Sci, vol.6, pp.199-209, 2014.

R. Forestier, H. Desfour, and J. M. Tessier, Spa therapy in the treatment of knee osteoarthritis: a large randomised multicentre trial, Ann Rheum Dis, vol.69, pp.660-665, 2010.

R. Forestier, C. Genty, and B. Waller, Crenobalneotherapy (spa therapy) in patients with knee and generalized osteoarthritis: a post-hoc subgroup analysis of a large multicentre randomized trial, Ann Phys Rehab Med, vol.57, pp.213-240, 2014.

W. C. Bornemeier, Avoidable hospitalization, Ill Med J, vol.104, pp.325-331, 1953.

J. Billings, L. Zeitel, J. Lukomnik, T. S. Carey, A. E. Blank et al., Impact of socioeconomic status on hospital use in New York City, Health Aff, vol.12, pp.162-73, 1993.

A. B. Bindman, K. Grumbach, and D. Osmond, Preventable hospitalizations and access to health care, JAMA, vol.274, pp.305-316, 1995.

J. S. Weissman, C. Gatsonis, and A. M. Epstein, Rates of avoidable hospitalization by insurance status in Massachusetts and Maryland, JAMA, vol.268, pp.2388-94, 1992.

A. Rosano, C. A. Loha, and R. Falvo, The relationship between avoidable hospitalization and accessibility to primary care: a systematic review, Eur J Public Health, vol.23, pp.356-60, 2013.

, Atlas de la fragilité du Languedoc-Roussillon retraités de 55 à 74 ans du régime général. Analyse spatiale et évolution temporelle. Diagnostic régional, diagnostics départementaux. Observatoire des situations de fragilité des personnes âgées, 2012.

B. Samolinski, A. Fronczak, A. Wlodarczyk, and J. Bousquet, Council of the European Union conclusions on chronic respiratory diseases in children, Lancet, vol.379, pp.45-51, 2012.

J. Bousquet, C. C. Tanasescu, and T. Camuzat, Impact of early diagnosis and control of chronic respiratory diseases on active and healthy ageing. A debate at the European Union parliament, Allergy, vol.68, pp.555-61, 2013.

J. Bousquet, J. E. Gern, and F. D. Martinez, Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop, Allergy Clin Immunol, vol.133, pp.1535-1581, 2014.