Cyclic Peptide–Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Biomacromolecules Année : 2017

Cyclic Peptide–Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes

Sophie Larnaudie
  • Fonction : Auteur
Johannes Brendel
  • Fonction : Auteur
Isolda Romero-Canelón
  • Fonction : Auteur
Carlos Sanchez-Cano
  • Fonction : Auteur
Joaquin Sanchis
  • Fonction : Auteur
James Coverdale
  • Fonction : Auteur
Ji-Inn Song
  • Fonction : Auteur
Abraha Habtemariam
  • Fonction : Auteur
Peter Sadler
  • Fonction : Auteur
Katrina Jolliffe
Sébastien Perrier
  • Fonction : Auteur

Résumé

Functional drug carrier systems have potential for increasing solubility and potency of drugs while reducing side effects. Complex polymeric materials, particularly anisotropic structures, are especially attractive due to their long circulation times. Here, we have conjugated cyclic peptides to the biocompatible polymer poly(2-hydroxypropyl methacrylamide) (pHPMA). The resulting conjugates were functionalized with organoiridium anticancer complexes. Small angle neutron scattering and static light scattering confirmed their self-assembly and elongated cylindrical shape. Drug-loaded nanotubes exhibited more potent antiproliferative activity toward human cancer cells than either free drug or the drug-loaded polymers, while the nanotubes themselves were nontoxic. Cellular accumulation studies revealed that the increased potency of the conjugate appears to be related to a more efficient mode of action rather than a higher cellular accumulation of iridium.

Domaines

Chimie

Dates et versions

hal-01700838 , version 1 (05-02-2018)

Identifiants

Citer

Sophie Larnaudie, Johannes Brendel, Isolda Romero-Canelón, Carlos Sanchez-Cano, Sylvain Catrouillet, et al.. Cyclic Peptide–Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes. Biomacromolecules, 2017, 19 (1), pp.239 - 247. ⟨10.1021/acs.biomac.7b01491⟩. ⟨hal-01700838⟩
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