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Article Dans Une Revue Colloids and Surfaces B: Biointerfaces Année : 2013

Thin phosphatidylcholine films as background surfaces with further possibilities of functionalization for biomedical applications

Lara Tauk
  • Fonction : Auteur
Thierry Thami
Jean-Marc Janot
Philippe Dejardin
  • Fonction : Auteur
  • PersonId : 1089599

Résumé

Non-specific adsorption is a crucial problem in the biomedical field. To produce surfaces avoiding this phenomenon, we functionalized thin (7–180 nm) poly(methylhydrosiloxane) (PMHS) network films at room temperature (≈20 °C) with phospholipids (PL) bearing a phosphorylcholine head. Regardless of their mode of preparation (casting or immersion), all surfaces appeared to be very hydrophilic with a captive air-bubble contact angle stabilized around 40°. The thin films were protein-repellent in phosphate saline buffer pH 7.4 according to analysis by normal scanning confocal fluorescence. Neither was any adsorption or spreading of l-α-phosphatidylcholine liposomes on such films observed. In addition, amino functional groups could be easily attached to the surface remaining available for further functionalization.

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hal-01688768 , version 1 (28-01-2021)

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Lara Tauk, Thierry Thami, Lynda Ferez, Armagan Kocer, Jean-Marc Janot, et al.. Thin phosphatidylcholine films as background surfaces with further possibilities of functionalization for biomedical applications. Colloids and Surfaces B: Biointerfaces, 2013, 101, pp.189 - 195. ⟨10.1016/j.colsurfb.2012.06.028⟩. ⟨hal-01688768⟩
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