DMSXL mice Myostatin Antisense oligonucleotides CONGENITAL MYATHENIC SYNDROME Dilated cardiomyopathy CRISPRi Muscle RNA biology CRISPR/Cas9 RNA splicing ACETYLCHOLINESTERASE Autophagy KNOCKOUT MICE Transgenic mouse model Male Oligodendrocytes Endurance training Astrocytes In vivo PCR RNA interference Long read sequencing Thérapie génique Gene therapy Trinucleotide Repeat Expansion Neuron Heart failure Humans Skeletal muscle Exercice CMS Myotonic dystrophy mouse models Acetylcholinesterase deficiency Hypoxia PacBio GABA Cardiac muscle Myotonic Dystrophy Myotonic Dystrophy Type 1 Glial cells CTG repeats Dynamin 2 Myelin Duchenne muscular dystrophy Glucocorticoid-receptor Heart Exercise Alternative splicing Astrocyte Knockout Glucocorticoids Fibrosis Brain dysfunction Intermediate filament Mouse models Dystrophie Myotonique BIOLOGIE MOLECULAIRE Acute coronary syndrome Transcriptomics Myotonic Dystrophy type 1 Maximal force Mice Cell culture model AAV Animals Gene editing Aging Expression Mouse model ARN MBNL Therapy Gene Therapy CTG repeat instability Dystrophin Centronuclear myopathy Dystrophie myotonique Glutamate Acetylcholinesterase knockout mouse Quantitative microdialysis Cell penetrating peptide Brain Diaphragm Myotonic dystrophy type 1 Muscular dystrophy Cytoskeleton DMPK Myotonic dystrophy Desmin GSK3␤ Antisense oligonucleotide Trinucleotide repeat expansion Central nervous system Transgenic mouse Oligodendrocyte Cell model Genotype phenotype correlation DM1 Motoneuron CTG repeat contractions