Myotonic dystrophy mouse models Gene Therapy Intermediate filament ARN Myostatin Gene therapy BIOLOGIE MOLECULAIRE DM1 Antisense oligonucleotides CTG repeat contractions Transgenic mouse Dystrophie myotonique de type 1 Cultured Astrocytes Myotonic Dystrophy type 1 Astrocyte PCR GABA Exercise Desmin Endurance training Myotonic Dystrophy Heart Exercice Skeletal muscle Dystrophin Mice Glucocorticoid-receptor RNA splicing Cell penetrating peptide Transgenic mouse model Cardiac muscle DMPK Brain dysfunction Alternative splicing Aging Brain Centronuclear myopathy Autophagy CMS Myotonic dystrophy type 1 GSK3␤ CTG repeats DMSXL mice Expression Motoneuron Central nervous system Thérapie génique Dilated cardiomyopathy Cardiac muscles Dystrophie Myotonique Mouse models Antisense oligonucleotide Oligodendrocyte Transcriptomics RNA biology Fibrosis Cardiovascular physiology PacBio Myotonic dystrophy CRISPRi RNA ACETYLCHOLINESTERASE Therapy Neurons Cells Acetylcholinesterase knockout mouse MBNL Muscle AAV KNOCKOUT MICE Oligodendrocytes Animals Axonal transport CTG repeat instability Trinucleotide Repeat Expansion Myotonic Dystrophy Type 1 Dystrophie myotonique CRISPR/Cas9 Quantitative microdialysis Mouse model Cytoskeleton Maximal force Myelin Acetylcholinesterase deficiency Trinucleotide repeat expansion CONGENITAL MYATHENIC SYNDROME Gene editing Cell culture model Long read sequencing Male Genotype phenotype correlation Acute coronary syndrome Glutamate Diaphragm Neuron Duchenne muscular dystrophy Muscular dystrophy Cell model Muscle contraction