Skip to Main content Skip to Navigation
Journal articles

Tissue damage from neutrophil-induced oxidative stress in COVID-19

Mireille Laforge 1 Carole Elbim 2 Corinne Frère 3 Miryana Hémadi 4 Charbel Massaad 1 Philippe Nuss 2 Jean-Jacques Benoliel 5 Chrystel Becker 1
1 T3S - UMR_S 1124 - Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire
2 CR Saint-Antoine - Centre de Recherche Saint-Antoine
3 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition
4 ITODYS (UMR_7086) - Interfaces, Traitements, Organisation et Dynamique des Systèmes
5 CHU Pitié-Salpêtrière [AP-HP]
Abstract : The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients.
Document type :
Journal articles
Complete list of metadatas
https://hal.archives-ouvertes.fr/hal-03091080
Contributor : Mireille Laforge <>
Submitted on : Tuesday, January 5, 2021 - 3:36:49 PM
Last modification on : Monday, January 11, 2021 - 11:51:31 AM

File

Vignette du document
NRI 2020 .pdf
Files produced by the author(s)

Identifiers

  • HAL Id : hal-03091080, version 1

Collections

CNRS | U938 | ICAN | SU-MEDECINE | UP-SCIENCES | SORBONNE-UNIVERSITE | UNIV-PARIS | SU-TI | INSERM

Citation

Mireille Laforge, Carole Elbim, Corinne Frère, Miryana Hémadi, Charbel Massaad, et al.. Tissue damage from neutrophil-induced oxidative stress in COVID-19. Nature Reviews Immunology, Nature Publishing Group, 2020, 20, pp.515-516. ⟨hal-03091080⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

25

Files downloads

5