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Tissue damage from neutrophil-induced oxidative stress in COVID-19

Abstract : The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients.
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Contributor : Mireille Laforge <>
Submitted on : Tuesday, January 5, 2021 - 3:36:49 PM
Last modification on : Monday, January 11, 2021 - 11:51:31 AM


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Mireille Laforge, Carole Elbim, Corinne Frère, Miryana Hémadi, Charbel Massaad, et al.. Tissue damage from neutrophil-induced oxidative stress in COVID-19. Nature Reviews Immunology, Nature Publishing Group, 2020, 20, pp.515-516. ⟨hal-03091080⟩



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