Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report
Antoine Yrondi
(1, 2, 3)
,
Guillaume Vaiva
(1, 4)
,
Michel Walter
(1, 5, 6)
,
Thierry D Amato
(1, 7, 8)
,
Frank Bellivier
(1, 9, 10)
,
Djamila Bennabi
(1, 11, 12)
,
Thierry Bougerol
(1, 13, 14)
,
Vincent Camus
(1, 15, 16)
,
Olivier Doumy
(1, 17, 18)
,
Jean-Baptiste Genty
(1, 19)
,
Emmanuel Haffen
(1, 11, 12)
,
Jérôme Holtzmann
(1, 13, 14)
,
Mathilde Horn
(1, 4)
,
Christophe Lançon
(1, 20)
,
Marion Leboyer
(1, 19)
,
Pierre-Michel Llorca
(1, 21, 22)
,
Julia Maruani
(1, 9, 10)
,
Rémi Moirand
(1, 7, 8)
,
Fanny Molière
(1, 23, 24)
,
Jean Petrucci
(1, 19)
,
Raphaelle Richieri
(1, 20)
,
Ludovic Samalin
(1, 21, 22)
,
Laurent Schmitt
(1, 2, 3)
,
Florian Stephan
(1, 5, 6)
,
Philippe Courtet
(1, 23, 24)
,
Wissam El-Hage
(1, 15, 16)
,
Bruno Aouizerate
(1, 17, 18)
,
V. Barteau
,
S. Bensalem
,
H. Laouamri
,
Karmene Souryis
,
L. Mallet
,
L. Yon
,
D. Pierre
,
M. Sarrail
,
I. Ryff
,
E. Beuchet
,
G. Tio
,
C. Cappe
,
E. Clerc
,
M. Garnier
,
R.M. Honciuc
,
E. Allauze
,
O. Blanc
,
N. Allaili
,
I. Nieto
,
J. Meheust
,
Y. Sunthavy
,
M. Polosan
,
P. Courvoisier
,
B. Fredembach
,
S. Foubert-Andreani
,
F. Haesebaert
,
C. Dubien
,
M. Lefebvre
,
A. Meznad
,
J. Brunelin
,
P. Peri
,
M. Faugere
,
C. Faget-Agius
,
J.P. Boulenger
,
C. Mesmeur
1
Fondation FondaMental [Créteil]
2 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
3 ToNIC - Toulouse NeuroImaging Center
4 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
5 CHU - BREST - Hopital de Bohars - CHRU Brest
6 EA7479 SPURBO - Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale
7 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
8 Centre Hospitalier le Vinatier [Bron]
9 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
10 OPTeN (UMR_S 1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie
11 Inserm CIC 1431 - Centre d'Investigation Clinique de Besançon
12 NEURO - Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481)
13 GIN - [GIN] Grenoble Institut des Neurosciences
14 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
15 iBraiN - Imaging, Brain & Neuropsychiatry
16 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
17 Centre hospitalier Charles Perrens [Bordeaux]
18 NutriNeuro - Nutrition et Neurobiologie intégrée
19 CHU Henri Mondor [Créteil]
20 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
21 CHU Clermont-Ferrand
22 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux
23 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
24 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
2 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
3 ToNIC - Toulouse NeuroImaging Center
4 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
5 CHU - BREST - Hopital de Bohars - CHRU Brest
6 EA7479 SPURBO - Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale
7 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
8 Centre Hospitalier le Vinatier [Bron]
9 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
10 OPTeN (UMR_S 1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie
11 Inserm CIC 1431 - Centre d'Investigation Clinique de Besançon
12 NEURO - Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481)
13 GIN - [GIN] Grenoble Institut des Neurosciences
14 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
15 iBraiN - Imaging, Brain & Neuropsychiatry
16 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
17 Centre hospitalier Charles Perrens [Bordeaux]
18 NutriNeuro - Nutrition et Neurobiologie intégrée
19 CHU Henri Mondor [Créteil]
20 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
21 CHU Clermont-Ferrand
22 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux
23 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
24 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
Antoine Yrondi
- Function : Author
- PersonId : 785942
- ORCID : 0000-0002-2650-6080
- IdRef : 177141042
Guillaume Vaiva
- Function : Author
- PersonId : 918789
- ORCID : 0000-0003-2462-008X
Thierry D Amato
- Function : Author
- PersonId : 1290580
- ORCID : 0000-0001-8983-0315
Frank Bellivier
- Function : Author
- PersonId : 757742
- ORCID : 0000-0002-3660-6640
- IdRef : 070265062
Vincent Camus
- Function : Author
- PersonId : 20005
- IdHAL : vincent-b-camus
- ORCID : 0000-0002-6845-221X
- IdRef : 034516565
Emmanuel Haffen
- Function : Author
- PersonId : 753044
- IdHAL : emmanuel-haffen
- ORCID : 0000-0002-4091-518X
- IdRef : 068887825
Christophe Lançon
- Function : Author
- PersonId : 946496
- ORCID : 0000-0002-0661-5781
- IdRef : 067155677
Marion Leboyer
- Function : Author
- PersonId : 756830
- ORCID : 0000-0001-5473-3697
- IdRef : 089352475
Pierre-Michel Llorca
- Function : Author
- PersonId : 781416
- ORCID : 0000-0001-7438-8990
- IdRef : 05967797X
Rémi Moirand
- Function : Author
- PersonId : 1094251
Laurent Schmitt
- Function : Author
- PersonId : 759208
- ORCID : 0000-0002-7203-6032
- IdRef : 071007482
Philippe Courtet
- Function : Author
- PersonId : 833371
- ORCID : 0000-0002-6519-8586
- IdRef : 060385022
Wissam El-Hage
- Function : Author
- PersonId : 183525
- IdHAL : wissam-el-hage
- ORCID : 0000-0003-3877-0855
- IdRef : 068549679
Bruno Aouizerate
- Function : Author
- PersonId : 751079
- IdHAL : bruno-aouizerate
- ORCID : 0000-0002-7092-7747
- IdRef : 069471851
V. Barteau
- Function : Contributor
S. Bensalem
- Function : Contributor
H. Laouamri
- Function : Contributor
Karmene Souryis
- Function : Contributor
L. Mallet
- Function : Contributor
L. Yon
- Function : Contributor
D. Pierre
- Function : Contributor
M. Sarrail
- Function : Contributor
I. Ryff
- Function : Contributor
E. Beuchet
- Function : Contributor
G. Tio
- Function : Contributor
C. Cappe
- Function : Contributor
E. Clerc
- Function : Contributor
M. Garnier
- Function : Contributor
R.M. Honciuc
- Function : Contributor
E. Allauze
- Function : Contributor
O. Blanc
- Function : Contributor
N. Allaili
- Function : Contributor
I. Nieto
- Function : Contributor
J. Meheust
- Function : Contributor
Y. Sunthavy
- Function : Contributor
M. Polosan
- Function : Contributor
P. Courvoisier
- Function : Contributor
B. Fredembach
- Function : Contributor
S. Foubert-Andreani
- Function : Contributor
F. Haesebaert
- Function : Contributor
- PersonId : 1191001
- ORCID : 0000-0002-6813-9012
- IdRef : 14712932X
C. Dubien
- Function : Contributor
M. Lefebvre
- Function : Contributor
A. Meznad
- Function : Contributor
J. Brunelin
- Function : Contributor
- PersonId : 752382
- IdHAL : jbrunelin
- ORCID : 0000-0001-5479-5628
- IdRef : 124622356
P. Peri
- Function : Contributor
M. Faugere
- Function : Contributor
C. Faget-Agius
- Function : Contributor
J.P. Boulenger
- Function : Contributor
C. Mesmeur
- Function : Contributor
Abstract
Objective: In addition to heredity, exposure to early-life adversity is an important predisposing risk factor of suicidal behaviour. Although the association between Childhood Trauma (CT) and suicide risk is well documented, interactions between CT and suicidal behaviour in Treatment-Resistant Depression (TRD) populations have received little coverage. This study aimed to evaluate i) association between CT and suicidal behaviour in a TRD population, and ii) the role of personality traits and impulsiveness as potential factors of mediation in these associations.
Methods: Patients were recruited from a cohort of the French network of TRD expert centers. Depressive symptom severity, CT, suicidal behaviour, personality traits, and impulsiveness were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS), the Childhood Trauma Questionnaire (CTQ), the Columbia Suicide Severity Rating Scale (CSSRS), the Structured Clinical Interview for DSM-IV, the Big Five Inventory, and the Barratt Impulsivness Scale (BIS) respectively.
Results: Among the 256 patients with a baseline CTQ, in relation to suicide risk for the current depressive episode, we found an association with the total CTQ scores mediated by the intensity of the current episode in a model adjusted for age and sex (total effect: β = 0.171; p = 0.011, direct effect: β = 0.135; p = 0.043; indirect effect: β = 0.036; p = 0.048). Focusing on CT subtypes, we detected an association between suicide risk and physical neglect in a model adjusted for age and sex (β = 0.301; p = 0.002), without any mediation by the intensity of the current episode. There was no mediation effect from personality traits nor impulsiveness. With regards to CSSRS to assess suicidal ideation, we did not find any association with the total CTQ score and CT subtype scores.
Conclusion: We report a strong association between suicidal behaviour and CT (in particular childhood physical neglect) in a TRD population.
Origin | Files produced by the author(s) |
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