Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease - PCCEI - Pathogenesis and Control of Chronic and Emerging Infections
Article Dans Une Revue Journal of Experimental Medicine Année : 2024

Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease

Adrian Gervais (1, 2) , Paul Bastard (3, 2, 4) , Lucy Bizien (3, 2) , Céline Delifer (5) , Pierre Tiberghien (5) , Chaturaka Rodrigo (6) , Francesca Trespidi (7) , Micol Angelini (7) , Giada Rossini (8) , Tiziana Lazzarotto (8, 9) , Francesca Conti (8, 9) , Irene Cassaniti (10, 11) , Fausto Baldanti (10, 11) , Francesca Rovida (10, 11) , Alessandro Ferrari (11) , Davide Mileto (12) , Alessandro Mancon (12) , Laurent Abel (3, 2, 4) , Anne Puel (3, 2, 4) , Aurélie Cobat (3, 2, 4) , Charles M Rice (13) , Dániel Cadar (14) , Jonas Schmidt-Chanasit (14, 15) , Johannes F Scheid (16, 17) , Jacob E Lemieux (16, 17) , Eric S Rosenberg (16, 17) , Marianna Agudelo (13) , Stuart G Tangye (18, 6) , Alessandro Borghesi (7, 19) , Guillaume André Durand (20, 21) , Emilie Duburcq-Gury (22) , Braulio M Valencia (23) , Andrew R Lloyd (23) , Anna Nagy (24) , Margaret M Macdonald (13) , Yannick Simonin (25) , Shen-Ying Zhang (3, 2, 4) , Jean-Laurent Casanova (3, 2, 4, 26)
1 Equipe Inserm U1163 - Human genetics of infectious diseases : Mendelian predisposition
2 Hôpital Necker - Enfants Malades [AP-HP]
3 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
4 St. Giles Laboratory of Human Genetics of Infectious Diseases
5 EFS - Etablissement Français du Sang [La Plaine Saint-Denis]
6 UNSW - University of New South Wales [Sydney]
7 IRCCS "San Matteo" Hospital Foundation [Pavie, Italie]
8 AOUB - IRCCS Azienda Ospedaliero-Universitaria di Bologna
9 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
10 UNIPV - Università degli Studi di Pavia [Italia] = University of Pavia [Italy] = Université de Pavie [Italie]
11 Fondazione IRCCS Policlinico San Matteo [Pavia]
12 ASST Fatebenefratelli-Sacco [Milan, Italy]
13 Rockefeller University [New York]
14 BNITM - Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany]
15 University of Hamburg
16 Massachusetts General Hospital [Boston]
17 HMS - Harvard Medical School [Boston]
18 Garvan Institute of medical research
19 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
20 IRBA - Institut de Recherche Biomédicale des Armées [Antenne Marseille]
21 UVE - Unité des Virus Emergents
22 Hôpital Saint Philibert [Lomme]
23 UNSW - The Kirby Institute for Infection and Immunity in Society
24 National center for public health [Hungary]
25 PCCEI - Pathogenesis and Control of Chronic and Emerging Infections
26 HHMI - Howard Hughes Medical Institute
Adrian Gervais
Human genetics of infectious diseases : Mendelian predisposition
Hôpital Necker - Enfants Malades [AP-HP]
Paul Bastard
Imagine - Institut des maladies génétiques (IHU)
Hôpital Necker - Enfants Malades [AP-HP]
St. Giles Laboratory of Human Genetics of Infectious Diseases
Lucy Bizien
Imagine - Institut des maladies génétiques (IHU)
Hôpital Necker - Enfants Malades [AP-HP]
Céline Delifer
Etablissement Français du Sang [La Plaine Saint-Denis]
Pierre Tiberghien
Etablissement Français du Sang [La Plaine Saint-Denis]
Chaturaka Rodrigo
University of New South Wales [Sydney]
Francesca Trespidi
IRCCS "San Matteo" Hospital Foundation [Pavie, Italie]
Micol Angelini
IRCCS "San Matteo" Hospital Foundation [Pavie, Italie]
Giada Rossini
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Tiziana Lazzarotto
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Alma Mater Studiorum Università di Bologna = University of Bologna
Francesca Conti
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Alma Mater Studiorum Università di Bologna = University of Bologna
Irene Cassaniti
Università degli Studi di Pavia [Italia] = University of Pavia [Italy] = Université de Pavie [Italie]
Fondazione IRCCS Policlinico San Matteo [Pavia]
Fausto Baldanti
Università degli Studi di Pavia [Italia] = University of Pavia [Italy] = Université de Pavie [Italie]
Fondazione IRCCS Policlinico San Matteo [Pavia]
Francesca Rovida
Università degli Studi di Pavia [Italia] = University of Pavia [Italy] = Université de Pavie [Italie]
Fondazione IRCCS Policlinico San Matteo [Pavia]
Alessandro Ferrari
Fondazione IRCCS Policlinico San Matteo [Pavia]
Davide Mileto
ASST Fatebenefratelli-Sacco [Milan, Italy]
Alessandro Mancon
ASST Fatebenefratelli-Sacco [Milan, Italy]
Laurent Abel
Imagine - Institut des maladies génétiques (IHU)
Hôpital Necker - Enfants Malades [AP-HP]
St. Giles Laboratory of Human Genetics of Infectious Diseases
Anne Puel
Imagine - Institut des maladies génétiques (IHU)
Hôpital Necker - Enfants Malades [AP-HP]
St. Giles Laboratory of Human Genetics of Infectious Diseases
Aurélie Cobat
Imagine - Institut des maladies génétiques (IHU)
Hôpital Necker - Enfants Malades [AP-HP]
St. Giles Laboratory of Human Genetics of Infectious Diseases
Charles M Rice
Rockefeller University [New York]
Dániel Cadar
Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany]
Jonas Schmidt-Chanasit
Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany]
University of Hamburg
Johannes F Scheid
Massachusetts General Hospital [Boston]
Harvard Medical School [Boston]
Jacob E Lemieux
Massachusetts General Hospital [Boston]
Harvard Medical School [Boston]
Eric S Rosenberg
Massachusetts General Hospital [Boston]
Harvard Medical School [Boston]
Marianna Agudelo
Rockefeller University [New York]
Stuart G Tangye
Garvan Institute of medical research
University of New South Wales [Sydney]
Alessandro Borghesi
IRCCS "San Matteo" Hospital Foundation [Pavie, Italie]
Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
Guillaume André Durand
Institut de Recherche Biomédicale des Armées [Antenne Marseille]
Unité des Virus Emergents
Emilie Duburcq-Gury
Hôpital Saint Philibert [Lomme]
Braulio M Valencia
The Kirby Institute for Infection and Immunity in Society
Andrew R Lloyd
The Kirby Institute for Infection and Immunity in Society
Anna Nagy
National center for public health [Hungary]
Margaret M Macdonald
Rockefeller University [New York]
Yannick Simonin
Pathogenesis and Control of Chronic and Emerging Infections
CV
Shen-Ying Zhang
Imagine - Institut des maladies génétiques (IHU)
Hôpital Necker - Enfants Malades [AP-HP]
St. Giles Laboratory of Human Genetics of Infectious Diseases
Jean-Laurent Casanova
Imagine - Institut des maladies génétiques (IHU)
Hôpital Necker - Enfants Malades [AP-HP]
St. Giles Laboratory of Human Genetics of Infectious Diseases
Howard Hughes Medical Institute

Résumé

Arboviral diseases are a growing global health concern. Pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) can underlie encephalitis due to West Nile virus (WNV) (∼40% of patients) and tick-borne encephalitis (TBE, due to TBE virus [TBEV]) (∼10%). We report here that these auto-Abs can also underlie severe forms of rarer arboviral infections. Auto-Abs neutralizing high concentrations of IFN-α2, IFN-β, and/or IFN-ω are present in the single case of severe Powassan virus (POWV) encephalitis studied, two of three cases of severe Usutu virus (USUV) infection studied, and the most severe of 24 cases of Ross River virus (RRV) disease studied. These auto-Abs are not found in any of the 137 individuals with silent or mild infections with these three viruses. Thus, auto-Abs neutralizing type I IFNs underlie an increasing list of severe arboviral diseases due to Flaviviridae (WNV, TBEV, POWV, USUV) or Togaviridae (RRV) viruses transmitted to humans by mosquitos (WNV, USUV, RRV) or ticks (TBEV, POWV).

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Soumis le : mardi 3 décembre 2024-11:23:47

Dernière modification le : samedi 14 décembre 2024-03:21:45

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hal-04816089 , version 1 (03-12-2024)

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Adrian Gervais, Paul Bastard, Lucy Bizien, Céline Delifer, Pierre Tiberghien, et al.. Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease. Journal of Experimental Medicine, 2024, 221 (12), pp.e20240942. ⟨10.1084/jem.20240942⟩. ⟨hal-04816089⟩

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