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In this work, we construct galactic halos in order to fit the rotation curves (RCs) of a sample of low surface brightness (LSB) galaxies. These halos are made of Fuzzy Dark Matter (FDM) with a multimode expansion of non-spherical modes that in average contribute to the appropriate density profile consisting of a core and an envelope needed to fit the rotation curves. These halos are constructed assuming a solitonic core at the center and two types of envelopes, Navarro-Frenk-White and Pseudo-Isothermal density profiles. The resulting FDM configurations are then evolved in order to show how the average density changes in time due to the secular dynamical evolution, along with a condensation process that lead to the growth of the solitonic core.

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We describe a complete methodology to bridge the scales between nanoscale molecular dynamics and (micrometer) mesoscale Monte Carlo simulations in lipid membranes and vesicles undergoing phase separation, in which curving molecular species are furthermore embedded. To go from the molecular to the mesoscale, we notably appeal to physical renormalization arguments enabling us to rigorously infer the mesoscale interaction parameters from its molecular counterpart. We also explain how to deal with the physical timescales at stake at the mesoscale. Simulating the as-obtained mesoscale system enables us to equilibrate the long wavelengths of the vesicles of interest, up to the vesicle size. Conversely, we then backmap from the meso- to the nano-scale, which enables us to equilibrate in turn the short wavelengths down to the molecular length-scales. By applying our approach to the specific situation of patterning a vesicle membrane, we show that macroscopic membranes can thus be equilibrated at all length-scales in achievable computational time offering an original strategy to address the fundamental challenge of timescale in simulations of large bio-membrane systems.

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A model of magnetic universe based on nonlinear electrodynamics has been introduced by Kruglov. This model describes an early inflation era followed by a radiation era. We show that this model is related to our model of universe based on a quadratic equation of state. We discuss two quantitatively different models of early universe. In Model I, the primordial density of the universe is identified with the Planck density. At $t=0$, the universe had the characteristics of a Planck black hole. During the inflation, which takes place on a Planck timescale, the size of the universe evolves from the Planck length to a size comparable to the Compton wavelength of the neutrino. If we interpret the radius of the universe at the end of the inflation (neutrino's Compton wavelength) as a minimum length related to quantum gravity and use Zeldovich's first formula of the vacuum energy, we obtain the correct value of the cosmological constant. In Model II, the primordial density of the universe is identified with the electron density as a consequence of nonlinear electrodynamics. At $t=0$, the universe had the characteristics of an electron. During the inflation, which takes place on a gravitoelectronic timescale, the size of the universe evolves from the electron's classical radius to a size comparable to the size of a dark energy star of the stellar mass. If we interpret the radius of the universe at the begining of the inflation (electron's classical radius) as a minimum length related to quantum gravity and use Zeldovich's second formula of the vacuum energy, we obtain the correct value of the cosmological constant. This provides an accurate form of Eddington relation between the cosmological constant and the mass of the electron. We also introduce a nonlinear electromagnetic Lagrangian that describes simultaneously the early inflation, the radiation era, and the dark energy era.

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A harmonically trapped active Brownian particle exhibits two types of positional distributions—one has a single peak and the other has a single well—that signify steady-state dynamics with low and high activity, respectively. Adding inertia to the translational motion preserves this strict classification of either single-peak or single-well densities but shifts the dividing boundary between the states in the parameter space. We characterize this shift for the dynamics in one spatial dimension using the static Fokker-Planck equation for the full joint distribution of the state space. We derive local results analytically with a perturbation method for a small rotational velocity and then extend them globally with a numerical approach.

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T-cell cytotoxic function relies on the cooperation between the highly specific but poorly adhesive T-cell receptor (TCR) and the integrin LFA-1. How LFA-1-mediated adhesion may scale with TCR stimulation strength is ill-defined. Here, we show that LFA-1 conformation activation scales with TCR stimulation to calibrate human T-cell cytotoxicity. Super-resolution microscopy analysis reveals that >1000 LFA-1 nanoclusters provide a discretized platform at the immunological synapse to translate TCR engagement and density of the LFA-1 ligand ICAM-1 into graded adhesion. Indeed, the number of high-affinity conformation LFA-1 nanoclusters increases as a function of TCR triggering strength. Blockade of LFA-1 conformational activation impairs adhesion to target cells and killing. However, it occurs at a lower TCR stimulation threshold than lytic granule exocytosis implying that it licenses, rather than directly controls, the killing decision. We conclude that the organization of LFA-1 into nanoclusters provides a calibrated system to adjust T-cell killing to the antigen stimulation strength.

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Subjets

Phase separation Einstein Collapse Diffusion Euler-Maclaurin Density Critical phenomena Mass density Thermodynamics Wave function Bethe ansatz Quantum chromodynamics axion Marcheur aléatoire Rotation Fermion Distributed Control Dark matter halo Computational modelling 9530Sf Cosmological constant Collective motion Chemotaxie Physique statistique Equation of state Dark matter Evaporation Smoluchowski-Poisson Dark matter theory 9880-k Galaxy Scalar field Kinetic theory Denaturation Brownian motion Axion Bose–Einstein condensates Nanofiltration Effect relativistic Bose-Einstein Scattering length Gravitation collapse Dark matter condensation Transition vitreuse Dark energy Expansion acceleration Collective behaviour Dissipation Mouvement brownien Hydrodynamics Fermion dark matter Collective behavior Atmosphere DNA Quantum mechanics Pressure Effondrement gravitationnel Energy internal Axion star Dark matter fuzzy Numerical calculations Collisionless stellar-systems Chemotaxis Gravitation Computational modeling Energy high Stability Energy density Nonrelativistic Fermi gas 9536+x Gravitation self-force Keller-Segel Asymptotic behavior Cosmological model Electromagnetic Current fluctuations Condensation Bose-Einstein Smoluchowski equation Black hole 9535+d Feedback Field theory scalar Fermions Cosmology Fokker-Planck Dark matter density 9862Gq Statistical mechanics Halo Gas Chaplygin Catastrophe theory Entropy Formation Competition Gravitational collapse Turbulence Random walker TASEP Structure General relativity

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