Enhanced spatial resolution of MALDI images using silicon masks
Abstract
This paper reports on simple, efficient and economical methods to increase MALDI image resolution. It is not currently possible to focus the diameter of a MALDI laser down to 50x50µm², i.e. 2500µm², without decreasing signal intensity. But using Silicon masks openings features, it might even be decreased to about 15x50µm², i.e. 750µm². Furthermore, the presence of a mask on the tissue section sample may result in a significant increase in the signal intensity for high m/z ratios. Finally, a huge advantage of the masks is their ease of adaptability on any MALDI mass spectrometer.
Domains
Physics [physics]
Origin : Files produced by the author(s)
