As the degradation of asphalt pavement surfaces under traffic loads is the primary factor affecting road network costs, it is crucial to assess the mixture responses at a micro-structural level to better understand and model the mixture deterioration behavior under real tire load conditions. Currently, many investigations are conducted within the framework of continuum mechanics to study the asphalt mixture responses under tire loads, which fails to capture the heterogeneous and discontinuous nature of asphalt mixtures adequately. To address this limitation, this study introduces a novel approach, employing a Finite Element Method-Discrete Element Method (FEM-DEM) coupling strategy, for modeling the tire-pavement interaction under rolling conditions. This approach incorporates non-uniform tire loads derived from a FEM tire model into a DEM model of asphalt mixtures containing irregular particles. By utilizing this coupling algorithm, it becomes possible to analyze the responses of asphalt mixtures at the particle scale under realistic tire load conditions, thereby offering fresh insights for the design of pavement surfaces.