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Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats

Benoît de Thoisy 1, * Olivier Duron 2, 3 Loïc Epelboin 4 Lise Musset 5, 6 Philippe Quénel 7, 8 Benjamin Roche 9, 2 Florian Binetruy 3 Sébastien Briolant 10, 11 Luisiane Carvalho 12 Agathe Chavy 1 Pierre Couppié 4 Magalie Demar 13, 14 Maylis Douine 15 I. Dusfour 16 Sébastien Gourbière 17 Yanouk Epelboin 18 Claude Flamand 19, 20 Alain Franc 21 Marine Ginouvès 14, 22 Emeline Houël 23 Arthur Kocher 24, 25 Anne Lavergne 1 Paul Le Turnier 26, 27 Luana Mathieu 7 Jérôme Murienne 25 Mathieu Nacher 15, 4 Roxane Schaub 13, 14, 15 Stéphane Pelleau 7, 28, 29 Ghislaine Prévot 13, 14 Dominique Rousset 1 Emmanuel Roux 30, 31 Stanislas Talaga 3, 18 Pauline Thill 32, 33 Sourakhata Tirera 1 Jean-François Guégan 3, 34, *
* Corresponding author
6 CCOMS - Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques - Laboratoire de parasitologie [Cayenne, Guyane française]
Institut Pasteur de la Guyane, OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office
9 MIVEGEC-CREEC - Centre de Recherches Ecologiques et Evolutives sur le Cancer
PEEC - Processus Écologiques et Évolutifs au sein des Communautés
22 TBIP - Biome Tropical et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille]
CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204, UG - Université de Guyane
Abstract : French Guiana is a European ultraperipheric region located on the northern Atlantic coast of South America. It constitutes an important forested region for biological conservation in the Neotropics. Although very sparsely populated, with its inhabitants mainly concentrated on the Atlantic coastal strip and along the two main rivers, it is marked by the presence and development of old and new epidemic disease outbreaks, both research and health priorities. In this review paper, we synthetize 15 years of multidisciplinary and integrative research at the interface between wildlife, ecosystem modification, human activities and sociodemographic development, and human health. This study reveals a complex epidemiological landscape marked by important transitional changes, facilitated by increased interconnections between wildlife, land-use change and human occupation and activity, human and trade transportation, demography with substantial immigration, and identified vector and parasite pharmacological resistance. Among other French Guianese characteristics, we demonstrate herein the existence of more complex multi-host disease life cycles than previously described for several disease systems in Central and South America, which clearly indicates that today the greater promiscuity between wildlife and humans due to demographic and economic pressures may offer novel settings for microbes and their hosts to circulate and spread. French Guiana is a microcosm that crystallizes all the current global environmental, demographic and socioeconomic change conditions, which may favor the development of ancient and future infectious diseases.
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Submitted on : Monday, June 21, 2021 - 1:42:46 PM
Last modification on : Thursday, September 9, 2021 - 11:27:00 AM

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Benoît de Thoisy, Olivier Duron, Loïc Epelboin, Lise Musset, Philippe Quénel, et al.. Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats. Infection, Genetics and Evolution, Elsevier, 2021, 93, pp.104916. ⟨10.1016/j.meegid.2021.104916⟩. ⟨pasteur-03261181⟩

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